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Famenini S,Lin B,Cassarino DS,Wu JJ
Hyperkeratotic papules on the medial aspects of the feet.
Cutis. 2017 Feb;99(2):E7-E8
PMID: 28319633

Zhang C,Kinsey N,Chen L,Ji C,Xu M,Ferrera M,Pan X,Shalaev VM,Boltasseva A,Guo LJ
High-Performance Doped Silver Films: Overcoming Fundamental Material Limits for Nanophotonic Applications.
Adv Mater. 2017 Mar 20;
The field of nanophotonics has ushered in a new paradigm of light manipulation by enabling deep subdiffraction confinement assisted by metallic nanostructures. However, a key limitation which has stunted a full development of high-performance nanophotonic devices is the typical large losses associated with the constituent metals. Although silver has long been known as the highest quality plasmonic material for visible and near infrared applications, its usage has been limited due to practical issues of continuous thin film formation, stability, adhesion, and surface roughness. Recently, a solution is proposed to the above issues by doping a proper amount of aluminum during silver deposition. In this work, the potential of doped silver for nanophotonic applications is presented by demonstrating several high-performance key nanophotonic devices. First, long-range surface plasmon polariton waveguides show propagation distances of a few centimeters. Second, hyperbolic metamaterials consisting of ultrathin Al-doped Ag films are attained having a homogeneous and low-loss response, and supporting a broad range of high-k modes. Finally, transparent conductors based on Al-doped Ag possess both a high and flat transmittance over the visible and near-IR range.
PMID: 28318121

Wang C,Xiao L,Luo R
Numerical interpretation of molecular surface field in dielectric modeling of solvation.
J Comput Chem. 2017 Mar 20;
Continuum solvent models, particularly those based on the Poisson-Boltzmann equation (PBE), are widely used in the studies of biomolecular structures and functions. Existing PBE developments have been mainly focused on how to obtain more accurate and/or more efficient numerical potentials and energies. However to adopt the PBE models for molecular dynamics simulations, a difficulty is how to interpret dielectric boundary forces accurately and efficiently for robust dynamics simulations. This study documents the implementation and analysis of a range of standard fitting schemes, including both one-sided and two-sided methods with both first-order and second-order Taylor expansions, to calculate molecular surface electric fields to facilitate the numerical calculation of dielectric boundary forces. These efforts prompted us to develop an efficient approximated one-dimensional method, which is to fit the surface field one dimension at a time, for biomolecular applications without much compromise in accuracy. We also developed a surface-to-atom force partition scheme given a level set representation of analytical molecular surfaces to facilitate their applications to molecular simulations. Testing of these fitting methods in the dielectric boundary force calculations shows that the second-order methods, including the one-dimensional method, consistently perform among the best in the molecular test cases. Finally, the timing analysis shows the approximated one-dimensional method is far more efficient than standard second-order methods in the PBE force calculations. © 2017 Wiley Periodicals, Inc.
PMID: 28318096

Wang L,Yu JY,Paek H
Enhanced biennial variability in the Pacific due to Atlantic capacitor effect.
Nat Commun. 2017 Mar 20;8:14887
The El Niño-Southern Oscillation (ENSO) and the variability in the Pacific subtropical highs (PSHs) have major impacts on social and ecological systems. Here we present an Atlantic capacitor effect mechanism to suggest that the Atlantic is a key pacemaker of the biennial variability in the Pacific including that in ENSO and the PSHs during recent decades. The 'charging' (that is, ENSO imprinting the North Tropical Atlantic (NTA) sea surface temperature (SST) via an atmospheric bridge mechanism) and 'discharging' (that is, the NTA SST triggering the following ENSO via a subtropical teleconnection mechanism) processes alternate, generating the biennial rhythmic changes in the Pacific. Since the early 1990s, a warmer Atlantic due to the positive phase of Atlantic multidecadal oscillation and global warming trend has provided more favourable background state for the Atlantic capacitor effect, giving rise to enhanced biennial variability in the Pacific that may increase the occurrence frequency of severe natural hazard events.
PMID: 28317857

Telles DR,Karki N,Marshall MW
Oral Fungal Infections: Diagnosis and Management.
Dent Clin North Am. 2017 Apr;61(2):319-349
Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. The review aids the dental practitioner in understanding the full scope of Candida infections and other fungal infections. In addition to candidiasis, various other fungal infections are reviewed, including mucormycosis, aspergillosis, blastomycosis, histoplasmosis, cryptococcosis, and coccidioidomycosis.
PMID: 28317569

Kang H,Ombao H,Fonnesbeck C,Ding Z,Morgan VL
A Bayesian Double Fusion Model for Resting State Brain Connectivity Using Joint Functional and Structural Data.
Brain Connect. 2017 Mar 19;
Current approaches separately analyze concurrently acquired diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) data. The primary limitation of these approaches is that they do not take advantage of the information from DTI that could potentially enhance estimation of resting state functional connectivity (FC) between brain regions. To overcome this limitation, we develop a Bayesian hierarchical spatio-temporal model that incorporates structural connectivity into estimating FC. In our proposed approach, structural connectivity (SC) based on DTI data is used to construct an informative prior for functional connectivity based on resting state fMRI data via the Cholesky decomposition. Simulation studies showed that incorporating the two data produced significantly reduced mean squared errors compared to the standard approach of separately analyzing the two data from different modalities. We applied our model to analyze the resting state DTI and fMRI data collected to estimate FC between the brain regions that were hypothetically important in the origination and spread of temporal lobe epilepsy seizures. Our analysis concludes that the proposed model achieves smaller false positive rates and is much robust to data decimation compared to the conventional approach.
PMID: 28316255

Schrock AB,Li SD,Frampton GM,Suh J,Braun E,Mehra R,Buck S,Bufill JA,Peled N,Karim NA,Hsieh C,Doria M,Knost J,Chen R,Ignatius Ou SH,Ross JS,Stephens PJ,Fishkin P,Miller VA,Ali SM,Halmos B,Liu JJ
Pulmonary sarcomatoid carcinomas commonly harbor either potentially targetable genomic alterations or high tumor mutational burden as observed by comprehensive genomic profiling.
J Thorac Oncol. 2017 Mar 15;
Pulmonary sarcomatoid carcinoma (PSC) is a high-grade non-small cell lung carcinoma (NSCLC) characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered due to limited and inconsistent molecular characterization.
PMID: 28315738

Temkin-Greener H,Ladwig S,Ye Z,Norton SA,Mukamel DB
Improving palliative care trough teamwork (IMPACTT) in nursing homes: Study design and baseline findings.
Contemp Clin Trials. 2017 Mar 14;
The 2014 Institute of Medicine report recommended that healthcare providers caring for individuals with advanced illness have basic palliative care competencies in communication, inter-professional collaboration, and symptom management. Nursing homes, where one in three American decedents live and die, have fallen short of these competency goals. We implemented an intervention study to examine the efficacy of nursing home-based integrated palliative care teams in improving the quality of care processes and outcomes for residents at the end of life.
PMID: 28315478

Robinette JW,Charles ST,Gruenewald TL
Neighborhood Socioeconomic Status and Health: A Longitudinal Analysis.
J Community Health. 2017 Mar 17;
Higher income neighborhoods are associated with better health, a relation observed in many cross-sectional studies. However, prior research focused on the prevalence of health conditions, and examining the incidence of new health conditions may provide stronger support for a potential causal role of neighborhoods on health. We used the 2004 and 2014 waves of the Midlife in the United States Study (n??=??1726; ages 34-83) to examine health condition incidence as a function of neighborhood income. Among participants who had lived in the same neighborhood across the time period, we hypothesized that higher neighborhood income would be associated with a lower incidence of health conditions ten years later. Health included 18 chronic conditions related to mental (anxiety, depression) and physical (cardiovascular, immune) health. Multinomial logistic regression analyses adjusting for individual income and sociodemographics indicated that the odds of developing two or more new health conditions (no new health conditions as referent), was significantly lower (OR??=??0.92, CI: 0.86, 0.99) for every $10,000 increment in neighborhood income. Associations did not vary by age or neighborhood tenure. Results add to a literature documenting that higher neighborhood income is associated with better health.
PMID: 28315111

Rugo HS,Seneviratne L,Beck JT,Glaspy JA,Peguero JA,Pluard TJ,Dhillon N,Hwang LC,Nangia C,Mayer IA,Meiller TF,Chambers MS,Sweetman RW,Sabo JR,Litton JK
Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial.
Lancet Oncol. 2017 Mar 14;
Stomatitis is a class effect associated with the inhibition of mTOR and is associated with everolimus therapy for breast cancer. Topical steroids might reduce stomatitis incidence and severity, and the need for dose reductions and interruptions of everolimus. Anecdotal use of topical steroid oral prophylaxis has been reported in patients with breast cancer. We aimed to assess dexamethasone-based mouthwash for prevention of stomatitis in patients with breast cancer.
PMID: 28314691

Chan V
Schizophrenia and Psychosis: Diagnosis, Current Research Trends, and Model Treatment Approaches with Implications for Transitional Age Youth.
Child Adolesc Psychiatr Clin N Am. 2017 Apr;26(2):341-366
This article reviews the current state of diagnosis and treatment of schizophrenia, describing the recent proliferation of research in high-risk psychosis spectrum conditions, which are different from childhood-onset and early onset schizophrenia, and findings of psychotic-like experiences in the normal population. Taken from adult and childhood literature, clinical quandaries in accurate diagnosis, and treatment gaps in co-occurring, or sometimes confounding, conditions are discussed. Thoughts on the impact of schizophrenia on an emerging adulthood trajectory are offered. Recent best practices in the treatment of schizophrenia are consistent with a recovery-oriented model of mental health services for transitional age youth.
PMID: 28314460

Ellis-Caleo T,Hegde JV,Bath S,Mesko S,Reiter R,Margolis D,Kamrava M
Imaging and Pathology Correlations for Different Risk Stratification Models for Intermediate-risk Prostate Cancer.
Anticancer Res. 2017 Mar;37(3):1237-1242
We evaluated whether sub-stratifying intermediate-risk (IR) prostate cancer using the Memorial Sloan Kettering Cancer (MSKCC) or Prostate Cancer Risk Stratification (ProCaRS) model predicts for adverse imaging or pathologic features.
PMID: 28314287

Kaganyuk M,Mohraz A
Non-monotonic dependence of Pickering emulsion gel rheology on particle volume fraction.
Soft Matter. 2017 Mar 17;
The microstructure of Pickering emulsion gels features a tenuous network of faceted droplets, bridged together by shared monolayers of particles. In this investigation, we use standard oscillatory rheometry in conjunction with confocal microscopy to gain a more comprehensive understanding of the role particle bridged interfaces have on the rheology of Pickering emulsion gels. The zero-shear elastic modulus of Pickering emulsion gels shows a non-monotonic dependence on particle loading, with three separate regimes of power-law and linear gel strengthening, and subsequent gel weakening. The transition from power-law to linear scaling is found to coincide with a peak in the volume fraction of particles that participate in bridging, which we indirectly calculate using measureable quantities, and the transition to gel weakening is shown to result from a loss in network connectivity at high particle loadings. These observations are explained via a simple representation of how Pickering emulsion gels arise from an initial population of partially-covered droplets. Based on these considerations, we propose a combined variable related to the initial droplet coverage, to be used in reporting and rationalizing the rheology of Pickering emulsion gels. We demonstrate the applicability of this variable with Pickering emulsions prepared at variable fluid ratios and with different-sized colloidal particles. The results of our investigation have important implications for many technological applications that utilize solid stabilized multi-phase emulsions and require a priori knowledge or engineering of their flow characteristics.
PMID: 28306753

Jaarsma T,Riegel B,Strömberg A
Reporting on Self-care in Research Studies: Guidance to Improve Knowledge Building.
J Cardiovasc Nurs. 2017 Mar 17;
PMID: 28306703

Xie HS,Xiao Y,Lin Z
New Paradigm for Turbulent Transport Across a Steep Gradient in Toroidal Plasmas.
Phys Rev Lett. 2017 Mar 03;118(9):095001
First principles gyrokinetic simulation of the edge turbulent transport in toroidal plasmas finds a reverse trend in the turbulent transport coefficients under strong gradients. It is found that there exist both linear and nonlinear critical gradients for the nonmonotonicity of transport characteristics. The discontinuity of the transport flux slope around the turning gradient shows features of a second order phase transition. Under a strong gradient the most unstable modes are in nonground eigenstates with unconventional mode structures, which significantly reduces the effective correlation length and thus reverse the transport trend. Our results suggest a completely new mechanism for the low to high confinement mode transition without invoking shear flow or zonal flow.
PMID: 28306291

Majd P,O'Connell DE,Kim RC,Bota DA,Carrillo JA
Case of glioblastoma patient treated with tumor treating fields therapy at recurrence degenerating to sarcoma.
CNS Oncol. 2017 Mar 17;
Optune(®) treatment is a US FDA-approved treatment for glioblastoma (GBM) that employs alternating electric fields. Tumor treating field (TTF) therapy can exert its effects on GBM via cell cycle mitosis disruption and cytokinesis. We describe a patient with recurrent GBM who had disease progression following standard surgical treatment and concomitant chemoradiotherapy, and was found to have sarcomatous transformation after initiation of TTF therapy with bevacizumab. Upon tumor progression, repeat surgical resection revealed transformation into a GFAP-negative, reticulin-positive sarcoma with rhabdomyoid features. The possibility of a causal connection between TTF therapy and sarcomatous transformation needs to be further evaluated. No such case of apparent sarcoma formation in the CNS following chemoradiotherapy and/or TTF treatment for GBM has been reported.
PMID: 28303729

Kleinman K,Huang SS
Calculating Power by Bootstrap, with an Application to Cluster-Randomized Trials.
EGEMS (Wash DC). 2016;4(1):1202
A key requirement for a useful power calculation is that the calculation mimic the data analysis that will be performed on the actual data, once that data is observed. Close approximations may be difficult to achieve using analytic solutions, however, and thus Monte Carlo approaches, including both simulation and bootstrap resampling, are often attractive. One setting in which this is particularly true is cluster-randomized trial designs. However, Monte Carlo approaches are useful in many additional settings as well. Calculating power for cluster-randomized trials using analytic or simulation-based methods is frequently unsatisfactory due to the complexity of the data analysis methods to be employed and to the sparseness of data to inform the choice of important parameters in these methods.
PMID: 28303254

Vahedifard F,AghaKouchak A,Ragno E,Shahrokhabadi S,Mallakpour I
Lessons from the Oroville dam.
Science. 2017 Mar 17;355(6330):1139-1140
PMID: 28302817

Elbir H,Sitlani P,Bergström S,Barbour AG
Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus.
Genome Announc. 2017 Mar 16;5(11)
Sequences of the linear chromosome and plasmids of Borrelia anserina, the cause of avian spirochetosis of poultry, revealed a smaller genome than those of other Borrelia spp. transmitted by argasid ticks. Missing or disrupted genes included a dam methylase and those in the pathway for synthesis of phospholipids from glycerol.
PMID: 28302772

Kim EE
Atlas of SPECT/CT.
J Nucl Med. 2017 Mar 16;
PMID: 28302758

Kowalewski M,Mukamel S
Manipulating molecules with quantum light.
Proc Natl Acad Sci U S A. 2017 Mar 16;
PMID: 28302671

Barbour K,McQuade M,Brown B
Students as effective harm reductionists and needle exchange organizers.
Subst Abuse Treat Prev Policy. 2017 Mar 17;12(1):15
Needle exchange programs are safe, highly effective programs for promoting health among people who inject drugs. However, they remain poorly funded, and often illegal, in many places worldwide due to fear and stigma surrounding drug use. Continued advocacy, education, and implementation of new needle exchanges are thus essential to improve public health and reduce structural inequality.
PMID: 28302153

Tran PN,Tran MH
Emerging Role of Direct Oral Anticoagulants in the Management of Heparin-Induced Thrombocytopenia.
Clin Appl Thromb Hemost. 2017 Jan 01;:1076029617696582
Heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia with thrombosis (HITT) are rare but potentially limb- and life-threatening complications of heparin therapy. Continuation of heparin or low-molecular-weight heparin is contraindicated due to platelet activation in the presence of (heparin-dependent) HIT antibodies. Primary treatment options currently include argatroban, fondaparinux, or bivalirudin. However, the parenteral administration routes and interference of argatroban with traditional coagulation markers complicate management. The goal of this review is to assess the viability of direct oral anticoagulants as an alternative treatment option in patients with HIT/HITT. Their use in HIT/HITT is reasonable, given absent cross-reactivity preformed with HIT antibodies. Furthermore, their rapid onset of action and induction of effective anticoagulation provide a favorable basis for their use in this condition. Herein, we summarize 3 studies and 8 case reports comprising 56 patients in whom direct oral anticoagulants were used in the treatment of HIT/HITT.
PMID: 28301915

Asvapathanagul P,Olson BH
Improving qPCR methodology for detection of foaming bacteria by analysis of broad-spectrum primers and a highly specific probe for quantification of Nocardia spp. in activated sludge.
J Appl Microbiol. 2017 Jan;122(1):97-105
To develop qPCR broad-spectrum primers combined with a Nocardia genus-specific probe for the identification of a broad spectrum of Nocardia spp. and to analyse the effects of using this developed primer and probe set on the ability to quantify Nocardia spp. in mixed DNA.
PMID: 27699950

Lindsay KL,Buss C,Wadhwa PD,Entringer S
The Interplay between Maternal Nutrition and Stress during Pregnancy: Issues and Considerations.
Ann Nutr Metab. 2017 Mar 17;
Several studies about humans and animals have separately examined the effects of prenatal nutrition and stress on fetal development, pregnancy, and birth outcomes, and subsequent child health and disease risk. Although substantial evidence from non-pregnant literature supports the presence of bidirectional interactions between nutrition and stress at various psychological, behavioral, and physiological levels, such interaction effects have not yet been systematically examined in the context of pregnancy.
PMID: 28301838


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