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Marcus GG,Kim DJ,Tutmaher JA,Rodriguez-Rivera JA,Birk JO,Niedermeyer C,Lee H,Fisk Z,Broholm CL
Multi-q Mesoscale Magnetism in CeAuSb_{2}.
Phys Rev Lett. 2018 Mar 02;120(9):097201
We report the discovery of a field driven transition from a single-q to multi-q spin density wave (SDW) in the tetragonal heavy fermion compound CeAuSb_{2}. Polarized along c, the sinusoidal SDW amplitude is 1.8(2)ľ_{B}/Ce for TŤT_{N}=6.25(10)??K with a wave vector q_{1}=(?,?,1/2) [?=0.136(2)]. For H?c, harmonics appearing at 2q_{1} evidence a striped magnetic texture below ľ_{°}H_{1}=2.78(1)??T. Above H_{1}, these are replaced by coupled harmonics at q_{1}+q_{2}=(2?,0,0)+c^{*} until ľ_{°}H_{2}=5.42(5)??T, where satellites vanish and magnetization nonlinearly approaches saturation at 1.64(2)ľ_{B}/Ce for ľ_{°}H˜7??T.
PMID: 29547324

Lertsakdadet B,Yang BY,Dunn CE,Ponticorvo A,Crouzet C,Bernal N,Durkin AJ,Choi B
Correcting for motion artifact in handheld laser speckle images.
J Biomed Opt. 2018 Mar;23(3):1-7
Laser speckle imaging (LSI) is a wide-field optical technique that enables superficial blood flow quantification. LSI is normally performed in a mounted configuration to decrease the likelihood of motion artifact. However, mounted LSI systems are cumbersome and difficult to transport quickly in a clinical setting for which portability is essential in providing bedside patient care. To address this issue, we created a handheld LSI device using scientific grade components. To account for motion artifact of the LSI device used in a handheld setup, we incorporated a fiducial marker (FM) into our imaging protocol and determined the difference between highest and lowest speckle contrast values for the FM within each data set (Kbest and Kworst). The difference between Kbest and Kworst in mounted and handheld setups was 8% and 52%, respectively, thereby reinforcing the need for motion artifact quantification. When using a threshold FM speckle contrast value (KFM) to identify a subset of images with an acceptable level of motion artifact, mounted and handheld LSI measurements of speckle contrast of a flow region (KFLOW) in in vitro flow phantom experiments differed by 8%. Without the use of the FM, mounted and handheld KFLOW values differed by 20%. To further validate our handheld LSI device, we compared mounted and handheld data from an in vivo porcine burn model of superficial and full thickness burns. The speckle contrast within the burn region (KBURN) of the mounted and handheld LSI data differed by
PMID: 29546735

Pham K,Turian E,Liu K,Li S,Lowengrub J
Nonlinear studies of tumor morphological stability using a two-fluid flow model.
J Math Biol. 2018 Mar 15;
We consider the nonlinear dynamics of an avascular tumor at the tissue scale using a two-fluid flow Stokes model, where the viscosity of the tumor and host microenvironment may be different. The viscosities reflect the combined properties of cell and extracellular matrix mixtures. We perform a linear morphological stability analysis of the tumors, and we investigate the role of nonlinearity using boundary-integral simulations in two dimensions. The tumor is non-necrotic, although cell death may occur through apoptosis. We demonstrate that tumor evolution is regulated by a reduced set of nondimensional parameters that characterize apoptosis, cell-cell/cell-extracellular matrix adhesion, vascularization and the ratio of tumor and host viscosities. A novel reformulation of the equations enables the use of standard boundary integral techniques to solve the equations numerically. Nonlinear simulation results are consistent with linear predictions for nearly circular tumors. As perturbations develop and grow, the linear and nonlinear results deviate and linear theory tends to underpredict the growth of perturbations. Simulations reveal two basic types of tumor shapes, depending on the viscosities of the tumor and microenvironment. When the tumor is more viscous than its environment, the tumors tend to develop invasive fingers and a branched-like structure. As the relative ratio of the tumor and host viscosities decreases, the tumors tend to grow with a more compact shape and develop complex invaginations of healthy regions that may become encapsulated in the tumor interior. Although our model utilizes a simplified description of the tumor and host biomechanics, our results are consistent with experiments in a variety of tumor types that suggest that there is a positive correlation between tumor stiffness and tumor aggressiveness.
PMID: 29546457

Mullins ME,Anavim A,Deitte LA,McLoud TC,Resnik CS
Diagnostic Radiology Resident Recruitment Part I: Advice to Programs (and Program Directors) From Vice Chairs for Education.
Acad Radiol. 2018 Mar 12;
To the best of our knowledge, there is little available organized advice for diagnostic radiology residency program directors and their programs regarding resident recruitment. We are a group of current and former program directors who are current vice chairs for education and continue to advise and to mentor many educators. We have constructed this article along the yearly schedule of trainee recruitment, including an application review, interviews, and troublesome trends that we have observed.
PMID: 29545024

Koepfli C,Yan G
Plasmodium Gametocytes in Field Studies: Do We Measure Commitment to Transmission or Detectability?
Trends Parasitol. 2018 Mar 12;
The proportion of Plasmodium spp. infections carrying gametocytes, and gametocyte densities, are often reported as surrogate markers for transmission potential. It remains unclear whether parasites under natural conditions adjust commitment to transmission depending on external factors. Population-based surveys comprising mostly asymptomatic low-density infections are always impacted by the sensitivity of the assays used to diagnose infections and detect gametocytes. Asexual parasite density is an important predictor for the probability of detecting gametocytes, and in many cases it can explain patterns in gametocyte carriage without the need for an adjustment of the gametocyte conversion rate. When reporting gametocyte data, quantification of blood-stage parasitemia and its inclusion as a confounder in multivariable analyses is essential.
PMID: 29544966

Hilty DM,Rabinowitz T,McCarron RM,Katzelnick DJ,Chang T,Bauer AM,Fortney J
An Update on Telepsychiatry and How It Can Leverage Collaborative, Stepped, and Integrated Services to Primary Care.
Psychosomatics. 2017 Dec 26;
In this era of patient-centered care, telepsychiatry (TP; video or synchronous) provides quality care with outcomes as good as in-person care, facilitates access to care, and leverages a wide range of treatments at a distance.
PMID: 29544663

Hyun KK,Jeong K,Tok A,Ritchie SG
Assessing crash risk considering vehicle interactions with trucks using point detector data.
Accid Anal Prev. 2018 Mar 12;
Trucks have distinct driving characteristics in general traffic streams such as lower speeds and limitations in acceleration and deceleration. As a consequence, vehicles keep longer headways or frequently change lane when they follow a truck, which is expected to increase crash risk. This study introduces several traffic measures at the individual vehicle level to capture vehicle interactions between trucks and non-trucks and analyzed how the measures affect crash risk under different traffic conditions. The traffic measures were developed using headways obtained from Inductive Loop Detectors (ILDs). In addition, a truck detection algorithm using a Gaussian Mixture (GM) model was developed to identify trucks and to estimate truck exposure from ILD data. Using the identified vehicle types from the GM model, vehicle interaction metrics were categorized into three groups based on the combination of leading and following vehicle types. The effects of the proposed traffic measures on crash risk were modeled in two different cases of prior- and non-crash using a case-control approach utilizing a conditional logistic regression. Results showed that the vehicle interactions between the leading and following vehicle types were highly associated with crash risk, and further showed different impacts on crash risk by traffic conditions. Specifically, crashes were more likely to occur when a truck following a non-truck had shorter average headway but greater headway variance in heavy traffic while a non-truck following a truck had greater headway variance in light traffic. This study obtained meaningful conclusions that vehicle interactions involved with trucks were significantly related to the crash likelihood rather than the measures that estimate average traffic condition such as total volume or average headway of the traffic stream.
PMID: 29544655

Tjoa T,Bunting G,Deschler DG
Injectable Soft-Tissue Augmentation for the Treatment of Tracheoesophageal Puncture Enlargement.
JAMA Otolaryngol Head Neck Surg. 2018 Mar 15;
PMID: 29543950

Karimzadeh A,Scarfone VM,Varady E,Chao C,Grathwohl K,Fathman JW,Fruman DA,Serwold T,Inlay MA
The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells.
Stem Cells Transl Med. 2018 Mar 15;
Hematopoietic stem cells (HSCs) are the self-renewing multipotent progenitors to all blood cell types. Identification and isolation of HSCs for study has depended on the expression of combinations of surface markers on HSCs that reliably distinguish them from other cell types. However, the increasing number of markers required to isolate HSCs has made it tedious, expensive, and difficult for newcomers, suggesting the need for a simpler panel of HSC markers. We previously showed that phenotypic HSCs could be separated based on expression of CD11a and that only the CD11a negative fraction contained true HSCs. Here, we show that CD11a and another HSC marker, endothelial protein C receptor (EPCR), can be used to effectively identify and purify HSCs. We introduce a new two-color HSC sorting method that can highly enrich for HSCs with efficiencies comparable to the gold standard combination of CD150 and CD48. Our results demonstrate that adding CD11a and EPCR to the HSC biologist's toolkit improves the purity of and simplifies isolation of HSCs. Stem Cells Translational Medicine 2018.
PMID: 29543389

Aartsen MG,Ackermann M,Adams J,Aguilar JA,Ahlers M,Ahrens M,Al Samarai I,Altmann D,Andeen K,Anderson T,Ansseau I,Anton G,Argüelles C,Auffenberg J,Axani S,Bagherpour H,Bai X,Barron JP,Barwick SW,Baum V,Bay R,Beatty JJ,Becker Tjus J,Becker KH,BenZvi S,Berley D,Bernardini E,Besson DZ,Binder G,Bindig D,Blaufuss E,Blot S,Bohm C,Börner M,Bos F,Bose D,Böser S,Botner O,Bourbeau J,Bradascio F,Braun J,Brayeur L,Brenzke M,Bretz HP,Bron S,Brostean-Kaiser J,Burgman A,Carver T,Casey J,Casier M,Cheung E,Chirkin D,Christov A,Clark K,Classen L,Coenders S,Collin GH,Conrad JM,Cowen DF,Cross R,Day M,de André JPAM,De Clercq C,DeLaunay JJ,Dembinski H,De Ridder S,Desiati P,de Vries KD,de Wasseige G,de With M,DeYoung T,Díaz-Vélez JC,di Lorenzo V,Dujmovic H,Dumm JP,Dunkman M,Eberhardt B,Ehrhardt T,Eichmann B,Eller P,Evenson PA,Fahey S,Fazely AR,Felde J,Filimonov K,Finley C,Flis S,Franckowiak A,Friedman E,Fuchs T,Gaisser TK,Gallagher J,Gerhardt L,Ghorbani K,Giang W,Glauch T,Glüsenkamp T,Goldschmidt A,Gonzalez JG,Grant D,Griffith Z,Haack C,Hallgren A,Halzen F,Hanson K,Hebecker D,Heereman D,Helbing K,Hellauer R,Hickford S,Hignight J,Hill GC,Hoffman KD,Hoffmann R,Hokanson-Fasig B,Hoshina K,Huang F,Huber M,Hultqvist K,Hünnefeld M,In S,Ishihara A,Jacobi E,Japaridze GS,Jeong M,Jero K,Jones BJP,Kalaczynski P,Kang W,Kappes A,Karg T,Karle A,Katz U,Kauer M,Keivani A,Kelley JL,Kheirandish A,Kim J,Kim M,Kintscher T,Kiryluk J,Kittler T,Klein SR,Kohnen G,Koirala R,Kolanoski H,Köpke L,Kopper C,Kopper S,Koschinsky JP,Koskinen DJ,Kowalski M,Krings K,Kroll M,Krückl G,Kunnen J,Kunwar S,Kurahashi N,Kuwabara T,Kyriacou A,Labare M,Lanfranchi JL,Larson MJ,Lauber F,Lennarz D,Lesiak-Bzdak M,Leuermann M,Liu QR,Lu L,Lünemann J,Luszczak W,Madsen J,Maggi G,Mahn KBM,Mancina S,Maruyama R,Mase K,Maunu R,McNally F,Meagher K,Medici M,Meier M,Menne T,Merino G,Meures T,Miarecki S,Micallef J,Momenté G,Montaruli T,Moore RW,Moulai M,Nahnhauer R,Nakarmi P,Naumann U,Neer G,Niederhausen H,Nowicki SC,Nygren DR,Obertacke Pollmann A,Olivas A,O'Murchadha A,Palczewski T,Pandya H,Pankova DV,Peiffer P,Pepper JA,Pérez de Los Heros C,Pieloth D,Pinat E,Plum M,Price PB,Przybylski GT,Raab C,Rädel L,Rameez M,Rawlins K,Rea IC,Reimann R,Relethford B,Relich M,Resconi E,Rhode W,Richman M,Robertson S,Rongen M,Rott C,Ruhe T,Ryckbosch D,Rysewyk D,Sälzer T,Sanchez Herrera SE,Sandrock A,Sandroos J,Sarkar S,Sarkar S,Satalecka K,Schlunder P,Schmidt T,Schneider A,Schoenen S,Schöneberg S,Schumacher L,Seckel D,Seunarine S,Soedingrekso J,Soldin D,Song M,Spiczak GM,Spiering C,Stachurska J,Stamatikos M,Stanev T,Stasik A,Stettner J,Steuer A,Stezelberger T,Stokstad RG,Stößl A,Strotjohann NL,Sullivan GW,Sutherland M,Taboada I,Tatar J,Tenholt F,Ter-Antonyan S,Terliuk A,Tešic G,Tilav S,Toale PA,Tobin MN,Toscano S,Tosi D,Tselengidou M,Tung CF,Turcati A,Turley CF,Ty B,Unger E,Usner M,Vandenbroucke J,Van Driessche W,van Eijndhoven N,Vanheule S,van Santen J,Vehring M,Vogel E,Vraeghe M,Walck C,Wallace A,Wallraff M,Wandler FD,Wandkowsky N,Waza A,Weaver C,Weiss MJ,Wendt C,Werthebach J,Westerhoff S,Whelan BJ,Wiebe K,Wiebusch CH,Wille L,Williams DR,Wills L,Wolf M,Wood J,Wood TR,Woolsey E,Woschnagg K,Xu DL,Xu XW,Xu Y,Yanez JP,Yodh G,Yoshida S,Yuan T,Zoll M,
Measurement of Atmospheric Neutrino Oscillations at 6-56 GeV with IceCube DeepCore.
Phys Rev Lett. 2018 Feb 16;120(7):071801
We present a measurement of the atmospheric neutrino oscillation parameters using three years of data from the IceCube Neutrino Observatory. The DeepCore infill array in the center of IceCube enables the detection and reconstruction of neutrinos produced by the interaction of cosmic rays in Earth's atmosphere at energies as low as ~5??GeV. That energy threshold permits measurements of muon neutrino disappearance, over a range of baselines up to the diameter of the Earth, probing the same range of L/E_{?} as long-baseline experiments but with substantially higher-energy neutrinos. This analysis uses neutrinos from the full sky with reconstructed energies from 5.6 to 56 GeV. We measure ?m_{32}^{2}=2.31_{-0.13}^{+0.11}×10^{-3}??eV^{2} and sin^{2}?_{23}=0.51_{-0.09}^{+0.07}, assuming normal neutrino mass ordering. These results are consistent with, and of similar precision to, those from accelerator- and reactor-based experiments.
PMID: 29542976

Csáki C,Shirman Y,Terning J,Waterbury M
Kaluza-Klein Monopoles and their Zero Modes.
Phys Rev Lett. 2018 Feb 16;120(7):071603
We find the conditions for the existence of fermionic zero modes of the fundamental representation in the background of a Kaluza-Klein (KK) monopole. We show that while there is no zero mode without a real mass, a normalizable zero mode appears once the real mass is sufficiently large. This provides an elegant explanation for the known decoupling of KK monopole effects in supersymmetric theories when a large real mass term is added. We also present an application where the correct counting of KK zero modes plays an essential role in understanding the nonperturbative effects determining the low-energy dynamics.
PMID: 29542947

Sun Z,Wang CY,Lawson DA,Kwek S,Velozo HG,Owyong M,Lai MD,Fong L,Wilson M,Su H,Werb Z,Cooke DL
Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells.
Oncotarget. 2018 Feb 16;9(13):10945-10961
Tumor endothelial cells (TEC) play an indispensible role in tumor growth and metastasis although much of the detailed mechanism still remains elusive. In this study we characterized and compared the global gene expression profiles of TECs and control ECs isolated from human breast cancerous tissues and reduction mammoplasty tissues respectively by single cell RNA sequencing (scRNA-seq). Based on the qualified scRNA-seq libraries that we made, we found that 1302 genes were differentially expressed between these two EC phenotypes. Both principal component analysis (PCA) and heat map-based hierarchical clustering separated the cancerous versus control ECs as two distinctive clusters, and MetaCore disease biomarker analysis indicated that these differentially expressed genes are highly correlated with breast neoplasm diseases. Gene Set Enrichment Analysis software (GSEA) enriched these genes to extracellular matrix (ECM) signal pathways and highlighted 127 ECM-associated genes. External validation verified some of these ECM-associated genes are not only generally overexpressed in various cancer tissues but also specifically overexpressed in colorectal cancer ECs and lymphoma ECs. In conclusion, our data demonstrated that ECM-associated genes play pivotal roles in breast cancer EC biology and some of them could serve as potential TEC biomarkers for various cancers.
PMID: 29541388

Suh JH,Schrock AB,Johnson A,Lipson D,Gay LM,Ramkissoon S,Vergilio JA,Elvin JA,Shakir A,Ruehlman P,Reckamp KL,Ou SI,Ross JS,Stephens PJ,Miller VA,Ali SM
Hybrid Capture-Based Comprehensive Genomic Profiling Identifies Lung Cancer Patients with Well-Characterized Sensitizing Epidermal Growth Factor Receptor Point Mutations That Were Not Detected by Standard of Care Testing.
Oncologist. 2018 Mar 14;
In our recent study, of cases positive for epidermal growth factor receptor () exon 19 deletions using comprehensive genomic profiling (CGP), 17/77 (22%) patients with prior standard of care (SOC)testing results available were previously negative for exon 19 deletion. Our aim was to compare the detection rates of CGP versus SOC testing for well-characterized sensitizingpoint mutations (pm) in our 6,832-patient cohort.
PMID: 29540602

Hallek M,Cheson BD,Catovsky D,Caligaris-Cappio F,Dighiero G,Döhner H,Hillmen P,Keating M,Montserrat E,Chiorazzi N,Stilgenbauer S,Rai KR,Byrd JC,Eichhorst B,O'Brien S,Robak T,Seymour JF,Kipps TJ
Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia.
Blood. 2018 Mar 14;
In 2008, International Workshop on CLL (iwCLL) published consensus guidelines for the design and conduct of clinical trials for patients with chronic lymphocytic leukemia (CLL) that were revised from those previously published by the National Cancer Institute-sponsored Working Group. These guidelines provided definitions intended to standardize the assessment of patients that were adopted by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the evaluation of new drugs. Since the publication of these guidelines there have been major advances in the biology and treatment of patients with CLL, prompting the iwCLL to evaluate and revise the 2008 criteria.
PMID: 29540348

Parihar VK,Maroso M,Syage A,Allen BD,Angulo MC,Soltesz I,Limoli CL
Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice.
Exp Neurol. 2018 Mar 11;
Of the many perils associated with deep space travel to Mars, neurocognitive complications associated with cosmic radiation exposure are of particular concern. Despite these realizations, whether and how realistic doses of cosmic radiation cause cognitive deficits and neuronal circuitry alterations several months after exposure remains unclear. In addition, even less is known about the temporal progression of cosmic radiation-induced changes transpiring over the duration of a time period commensurate with a flight to Mars. Here we show that rodents exposed to the second most prevalent radiation type in space (i.e. helium ions) at low, realistic doses, exhibit significant hippocampal and cortical based cognitive decrements lasting 1?year after exposure. Cosmic-radiation-induced impairments in spatial, episodic and recognition memory were temporally coincident with deficits in cognitive flexibility and reduced rates of fear extinction, elevated anxiety and depression like behavior. At the circuit level, irradiation caused significant changes in the intrinsic properties (resting membrane potential, input resistance) of principal cells in the perirhinal cortex, a region of the brain implicated by our cognitive studies. Irradiation also resulted in persistent decreases in the frequency and amplitude of the spontaneous excitatory postsynaptic currents in principal cells of the perirhinal cortex, as well as a reduction in the functional connectivity between the CA1 of the hippocampus and the perirhinal cortex. Finally, increased numbers of activated microglia revealed significant elevations in neuroinflammation in the perirhinal cortex, in agreement with the persistent nature of the perturbations in key neuronal networks after cosmic radiation exposure. These data provide new insights into cosmic radiation exposure, and reveal that even sparsely ionizing particles can disrupt the neural circuitry of the brain to compromise cognitive function over surprisingly protracted post-irradiation intervals.
PMID: 29540322

Sickerman NS,Tanifuji K,Hu Y,Ribbe MW
Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments.
Chemistry. 2017 Sep 12;23(51):12425-12432
Nitrogenase is the only known biological system capable of reducing Nto NH, which is a critical component of bioavailable nitrogen fixation. Since the discovery of discrete iron-sulfur metalloclusters within the nitrogenase MoFe protein, synthetic inorganic chemists have sought to reproduce the structural features of these clusters in order to understand how they facilitate the binding, activation and hydrogenation of N. Through the decades following the initial identification of these clusters, significant progress has been made to synthetically replicate certain compositional and functional aspects of the biogenic clusters. Although much work remains to generate synthetic iron-sulfur clusters that can reduce Nto NH, the insights borne from past and recent developments are discussed in this concept article.
PMID: 28726330

Bailey JN,de Nijs L,Bai D,Suzuki T,Miyamoto H,Tanaka M,Patterson C,Lin YC,Medina MT,Alonso ME,Serratosa JM,Durón RM,Nguyen VH,Wight JE,Martínez-Juárez IE,Ochoa A,Jara-Prado A,Guilhoto L,Molina Y,Yacubian EM,López-Ruiz M,Inoue Y,Kaneko S,Hirose S,Osawa M,Oguni H,Fujimoto S,Grisar TM,Stern JM,Yamakawa K,Lakaye B,Delgado-Escueta AV
Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy.
N Engl J Med. 2018 03 15;378(11):1018-1028
In juvenile myoclonic epilepsy, data are limited on the genetic basis of networks promoting convulsions with diffuse polyspikes on electroencephalography (EEG) and the subtle microscopic brain dysplasia called microdysgenesis.
PMID: 29539279

Mitchell JT,Howard AL,Belendiuk KA,Kennedy TM,Stehli A,Swanson JM,Hechtman L,Arnold LE,Hoza B,Vitiello B,Lu B,Kollins SH,Molina BSG
Cigarette Smoking Progression among Young Adults Diagnosed with ADHD in Childhood: A 16-year Longitudinal Study of Children with and without ADHD.
Nicotine Tob Res. 2018 Mar 12;
Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for smoking cigarettes, but there is little longitudinal research on the array of smoking characteristics known to be prognostic of long-term smoking outcomes into adulthood. These variables were studied into early adulthood in a multi-site sample diagnosed with ADHD combined-type at ages 7-9.9 and followed prospectively alongside an age- and sex-matched local normative comparison group (LNCG).
PMID: 29538764

Hou J,Williams J,Botvinick E,Potma E,Tromberg BJ
Visualization of breast cancer metabolism using multimodal non-linear optical microscopy of cellular lipids and redox state.
Cancer Res. 2018 Mar 13;
Label-free non-linear optical microscopy (NLOM) based on two-photon excited fluorescence (TPEF) from cofactors Nicotinamide Adenine Dinucleotide (NADH) and Flavin Adenine Dinucleotide (FAD+) is widely used for high-resolution cellular redox imaging. In this work, we combined three, label-free NLOM imaging methods to quantitatively characterize breast cancer cells and their relative invasive potential: 1) TPEF optical redox ratio (ORR = FAD+/NADH + FAD+), 2) coherent Raman scattering (CRS) of cellular lipids, and 3) second harmonic generation (SHG) of extracellular matrix (ECM) collagen. 3D spheroid models of primary mammary epithelial cells (PME) and breast cancer cell lines (T47D and MDA-MB-231) were characterized based on their unique ORR and lipid volume fraction signatures. Treatment with 17ß-estradiol (E2) increased glycolysis in both PME and T47D ER+ breast cancer cells. However, PME cells displayed increased lipid content with no ECM effect, while T47D cells had decreased lipid storage (p
PMID: 29535219

Rebelein JG,Lee CC,Newcomb M,Hu Y,Ribbe MW
Characterization of an M-Cluster-Substituted Nitrogenase VFe Protein.
MBio. 2018 Mar 13;9(2)
The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster). However, the V-nitrogenase is ~600-fold more active than its Mo counterpart in reducing CO to hydrocarbons at ambient conditions. Here, we expressed an M-cluster-containing, hybrid V-nitrogenase inand compared it to its native, V-cluster-containing counterpart in order to assess the impact of protein scaffold and cofactor species on the differential reactivities of Mo- and V-nitrogenases toward CO. Housed in the VFe protein component of V-nitrogenase, the M-cluster displayed electron paramagnetic resonance (EPR) features similar to those of the V-cluster and demonstrated an ~100-fold increase in hydrocarbon formation activity from CO reduction, suggesting a significant impact of protein environment on the overall CO-reducing activity of nitrogenase. On the other hand, the M-cluster was still ~6-fold less active than the V-cluster in the same protein scaffold, and it retained its inability to form detectable amounts of methane from CO reduction, illustrating a fine-tuning effect of the cofactor properties on this nitrogenase-catalyzed reaction. Together, these results provided important insights into the two major determinants for the enzymatic activity of CO reduction while establishing a useful framework for further elucidation of the essential catalytic elements for the CO reactivity of nitrogenase.This is the first report on thegeneration andcharacterization of an M-cluster-containing V-nitrogenase hybrid. The "normalization" of the protein scaffold to that of the V-nitrogenase permits a direct comparison between the cofactor species of the Mo- and V-nitrogenases (M- and V-clusters) in CO reduction, whereas the discrepancy between the protein scaffolds of the Mo- and V-nitrogenases (MoFe and VFe proteins) housing the same cofactor (M-cluster) allows for an effective assessment of the impact of the protein environment on the CO reactivity of nitrogenase. The results of this study provide a first look into the "weighted" contributions of protein environment and cofactor properties to the overall activity of CO reduction; more importantly, they establish a useful platform for further investigation of the structural elements attributing to the CO-reducing activity of nitrogenase.
PMID: 29535200

Jiang L,Chang J,Beals J,Bullock A,Manson SM,
Neighborhood characteristics and lifestyle intervention outcomes: Results from the Special Diabetes Program for Indians.
Prev Med. 2018 Mar 10;
Growing evidence reveals various neighborhood conditions are associated with the risk of developing type 2 diabetes. It is unknown, however, whether the effectiveness of diabetes prevention interventions is also influenced by neighborhood characteristics. The purpose of the current study is to examine the impact of neighborhood characteristics on the outcomes of a lifestyle intervention to prevent diabetes in American Indians and Alaska Natives (AI/ANs). Year 2000 US Census Tract data were linked with those from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), an evidence-based lifestyle intervention implemented in 36 AI/AN grantee sites across the US. A total of 3394 participants started the intervention between 01/01/2006 and 07/31/2009 and were followed by 07/31/2016. In 2016-2017, data analyses were conducted to evaluate the relationships of neighborhood characteristics with intervention outcomes, controlling for individual level socioeconomic status. AI/ANs from sites located in neighborhoods with higher median household income had 38% lower risk of developing diabetes than those from sites with lower neighborhood income (adjusted hazard ratio?=?0.62, 95% CI: 0.44, 0.88). Further, those from sites with higher neighborhood concentrations of AI/ANs achieved less BMI reduction and physical activity increase. Meanwhile, participants from sites with higher neighborhood level of vehicle occupancy made more improvement in BMI and diet. Lifestyle intervention effectiveness was not optimal when the intervention was implemented at sites with disadvantaged neighborhood characteristics. Meaningful improvements in socioeconomic and other neighborhood disadvantages of vulnerable populations could be important in stemming the global epidemic of diabetes.
PMID: 29534990

Aidoo EK,Afrane YA,Machani MG,Chebore W,Lawson BW,Atieli H,Kariuki S,Lee MC,Koepfli C,Zhou G,Githeko AK,Yan G
Reactive case detection of Plasmodium falciparum in western Kenya highlands: effective in identifying additional cases, yet limited effect on transmission.
Malar J. 2018 Mar 13;17(1):111
Identifying asymptomatic reservoirs of malaria parasites using index cases as entry points into the community is potentially a cost-effective way towards achieving malaria elimination.
PMID: 29534709

Bennett JM,Calosi P,Clusella-Trullas S,Martínez B,Sunday J,Algar AC,Araújo MB,Hawkins BA,Keith S,Kühn I,Rahbek C,Rodríguez L,Singer A,Villalobos F,Ángel Olalla-Tárraga M,Morales-Castilla I
GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms.
Sci Data. 2018 Mar 13;5:180022
How climate affects species distributions is a longstanding question receiving renewed interest owing to the need to predict the impacts of global warming on biodiversity. Is climate change forcing species to live near their critical thermal limits? Are these limits likely to change through natural selection? These and other important questions can be addressed with models relating geographical distributions of species with climate data, but inferences made with these models are highly contingent on non-climatic factors such as biotic interactions. Improved understanding of climate change effects on species will require extensive analysis of thermal physiological traits, but such data are both scarce and scattered. To overcome current limitations, we created the GlobTherm database. The database contains experimentally derived species' thermal tolerance data currently comprising over 2,000 species of terrestrial, freshwater, intertidal and marine multicellular algae, plants, fungi, and animals. The GlobTherm database will be maintained and curated by iDiv with the aim to keep expanding it, and enable further investigations on the effects of climate on the distribution of life on Earth.
PMID: 29533392

Sahyouni R,Mahboubi H,Moshtaghi O,Goshtasbi K,Sahyouni S,Lin HW,Djalilian HR
Radiosurgery of Glomus Tumors of Temporal Bone: a Meta-analysis.
Otol Neurotol. 2018 Apr;39(4):488-493
1) Perform a meta-analysis of the available data on the outcomes of stereotactic radiosurgery (SRS) for the treatment of temporal bone glomus tumors (GT), and 2) evaluate the collective outcomes of SRS treatment with respect to tumor control.
PMID: 29533338

Tayebi Khosroshahi H,Vaziri ND,Abedi B,Asl BH,Ghojazadeh M,Jing W,Vatankhah AM
Effect of high amylose resistant starch (HAM-RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial.
Hemodial Int. 2018 Mar 13;
Systemic inflammation and oxidative stress play a central role in the pathogenesis of cardiovascular disease and numerous other complications of CKD. Recent studies demonstrated that consumption of a diet enriched with amylose (HAM-RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients.
PMID: 29532981

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