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Hwang N,Domina T
The Links Between Youth Employment and Educational Attainment Across Racial Groups.
J Res Adolesc. 2017 Jun;27(2):312-327
Research suggests that the relations between adolescent employment and youth development vary by socioeconomic status (SES) and race/ethnicity. However, it is unclear whether the links between paid work and college outcomes vary by either SES or race/ethnicity, or both. Using data from the Educational Longitudinal Study, we find that low-intensity work during high school is associated with positive college outcomes for almost all students, whereas the associations between high-intensity work and negative postsecondary outcomes are mostly limited to White students. Our results suggest that both differential selections into youth employment and differential consequences of youth employment contribute to these varying links between paid work and educational outcomes across different racial groups.
PMID: 28876528

Moeller J,Dietrich J,Eccles JS,Schneider B
Passionate Experiences in Adolescence: Situational Variability and Long-Term Stability.
J Res Adolesc. 2017 Jun;27(2):344-361
This study investigates adolescents' situational passionate experiences, defined as states of strong commitment and intense affect. We examine the extent to which experiencing passion was specific to situations versus individual differences, and explore which activities are likely to elicit adolescents' passion. Using longitudinal experience sampling method (ESM) data from a representative sample of 996 adolescents (54.6% females) in three cohorts (6th, 8th, and 10th grade at baseline), we examine whether adolescents' frequency of passionate experiences remained stable across 2years. Results of multilevel analyses revealed that situational determinants accounted for 80% of variance in passion, while 20% were due to characteristics of the person that remained stable across 1week of ESM assessment. An adolescent's percentage of passionate experiences among all observed experiences remained stable across 2years in rank order and mean level.
PMID: 28876521

Larson SB,McPherson A
The structure of the Pfp1 protease from the hyperthermophilic archaeon Thermococcus thioreducens in two crystal forms.
Acta Crystallogr D Struct Biol. 2017 Sep 01;73(Pt 9):749-756
The Pfp1 protease, a cysteine protease of unknown specificity from the hyperthermophilic archaeon Thermococcus thioreducens, was crystallized in two distinctive crystal forms: from concentrated citrate in one case and PEG in the other. X-ray data were collected from both crystal forms at room temperature to about 1.9 resolution using a laboratory source and detector, and the structures were solved by molecular replacement using the Pfp1 protease from Pyrococcus horikoshii as the search model. In the T. thioreducens protease structures, Cys18 residues on adjacent molecules in the asymmetric units form intermolecular disulfide bonds, thereby yielding hexamers composed of three cross-linked, quasi-dyad-related dimers with crystallographically exact threefold axes and exhibiting almost exact 32 symmetry. The corresponding residue in P. horikoshii Pfp1 is Tyr18. An individual active site containing Cys100 and His101 also includes a Glu74 residue contributed by a quasi-twofold-related, non-cross-linked subunit. Two catalytic triads are therefore closely juxtaposed about the quasi-twofold axis at the interface of these subunits, and are relatively sequestered within the hexamer cavity. The cysteine in the active site is observed to be oxidized in both of the crystal forms that were studied.
PMID: 28876238

Kranke D,Weiss EL,Heslin KC,Dobalian A
"We Are Disaster Response Experts": A Qualitative Study on the Mental Health Impact of Volunteering in Disaster Settings Among Combat Veterans.
Soc Work Public Health. 2017 Sep 06;:1-10
Volunteers serving in a disaster context may experience harmful mental health effects that could impede rescue operations. Exploratory research suggests that combat veterans who volunteer in Team Rubicon (TR)-a disaster relief social service organization with the mission of uniting the skills and experiences of military Veterans with first responders to rapidly deploy emergency response teams-have positive mental health responses when providing disaster relief. The objective of this qualitative study was to identify those nuances associated with combat veterans' mental health response in TR. The study consisted of (N=9) male combat Veterans who volunteered with TR. Data was thematically analyzed. Results suggested that members did not experience negative mental health effects because of prior military training and preparedness relevant to disaster situations. Positive outcomes in mental health were associated with the uniqueness of peer support in TR and applying skills from military training. Veterans in TR reported that providing disaster relief afforded them the opportunity to continue serving others after having served in the military. Implications for public health social work are discussed as well as the need for further research.
PMID: 28876217

Mukherjee J,Lao PJ,Betthauser TJ,Samra GK,Pan ML,Patel IH,Liang C,Metherate R,Christian BT
Human Brain Imaging of Nicotinic Acetylcholine a42* Receptors using [(18) F]Nifene: Selectivity, Functional Activity, Toxicity, Aging Effects, Gender Effects and Extrathalamic Pathways.
J Comp Neurol. 2017 Sep 05;
Nicotinic acetylcholinergic receptors (nAChR's) have been implicated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease and schizophrenia. Here we report in vitro selectivity and functional properties, toxicity in rats, in vivo evaluation in humans, and comparison across species of [(18) F]Nifene, a fast acting PET imaging agent for a42* nAChRs. Nifene had subnanomolar affinities for ha22 (0.34 nM), ha32 (0.80 nM) and ha42 (0.83 nM) nAChR but weaker (27 to 219 nM) for h4 nAChR subtypes and 169 nM for ha7 nAChR. In functional assays, Nifene (100 M) exhibited 14% agonist and >50% antagonist characteristics. In 14-day acute toxicity in rats, the maximum tolerated dose (MTD) and the no observed adverse effect level (NOAEL) were estimated to exceed 40 g/kg/day (278 g/m(2) /day). In human PET studies, [(18) F]Nifene (185 MBq; 15% than males. No significant aging effect was observed in [(18) F]Nifene binding over 5 decades. In all species (mice, rats, monkeys and humans) thalamus showed highest [(18) F]Nifene binding with reference region ratios >2 compared to extrathalamic regions. Our findings suggest that [(18) F]Nifene PET may be used to study a42* nAChRs in various CNS disorders and for translational research. This article is protected by copyright. All rights reserved.
PMID: 28875553

Suez D,Stein M,Gupta S,Hussain I,Melamed I,Paris K,Darter A,Bourgeois C,Fritsch S,Leibl H,McCoy B,Gelmont D,Yel L
Response to the Letter to the Editor Regarding "Assessment of Local Adverse Reactions to Subcutaneous Immunoglobulin (SCIG) in Clinical Trials".
J Clin Immunol. 2017 Sep 05;
PMID: 28875256

Oakey Z,Thai K,Garg S
Bilateral corneal perforation due to MRSA keratitis in a crosslinking patient.
GMS Ophthalmol Cases. 2017;7:Doc21
Introduction: The cornea may become infected and perforated after epithelium-on collagen crosslinking. Case presentation: A healthy 33-year-old male who underwent corneal collagen crosslinking in both eyes developed a purulent keratitis and bilateral corneal perforations, requiring bilateral penetrating keratoplasties. He was exposed to methicillin resistant staphylococcus aureus (MRSA) by a family member with a tracheostomy and was treated with MRSA-directed antibiotics. After prolonged recovery and treatment of his infection, he had acceptable but limited uncorrected visual acuity, with excellent corrected visual acuity. Conclusion: While epithelium-on crosslinking is commonly thought to be associated with a lower risk of postoperative infection, this case illustrates that even epithelium-on treatment may present the patient with a risk of infection. Patients in higher risk groups who are exposed to infectious disease may be more predisposed.
PMID: 28875112

Pham QN,Barako MT,Tice J,Won Y
Microscale Liquid Transport in Polycrystalline Inverse Opals across Grain Boundaries.
Sci Rep. 2017 Sep 05;7(1):10465
Delivering liquid through the void spaces in porous metals is a daunting challenge for a variety of emerging interface technologies ranging from battery electrodes to evaporation surfaces. Hydraulic transport characteristics of well-ordered porous media are governed by the pore distribution, porosity, and morphology. Much like energy transport in polycrystalline solids, hydraulic transport in semi-ordered porous media is predominantly limited by defects and grain boundaries. Here, we report the wicking performances for porous copper inverse opals having pore diameters from 300 to 1000?nm by measuring the capillary-driven liquid rise. The capillary performance parameter within single crystal domain (K ij /R eff ?=?10(-3) to 10(-2)?m) is an order of magnitude greater than the collective polycrystal (K eff /R eff ?=?~10(-5) to 10(-3)?m) due to the hydraulic resistances (i.e. grain boundaries between individual grains). Inspired by the heterogeneity found in biological systems, we report thatthe capillary performance parameter of gradient porous copper (K eff /R eff ?=?~10(-3)?m), comparable to that of single crystals, overcomes hydraulic resistances through providing additional hydraulic routes in three dimensions. The understanding of microscopic liquid transport physics through porous crystals and across grain boundaries will help to pave the way for the spatial design of next-generation heterogeneous porous media.
PMID: 28874790

Zhang Q,Wu T,Chen C,Mukamel S,Zhuang W
Molecular mechanism of water reorientational slowing down in concentrated ionic solutions.
Proc Natl Acad Sci U S A. 2017 Sep 05;
Water dynamics in concentrated ionic solutions plays an important role in a number of material and energy conversion processes such as the charge transfer at the electrolyte-electrode interface in aqueous rechargeable ion batteries. One long-standing puzzle is that all electrolytes, regardless of their "structure-making/breaking" nature, make water rotate slower at high concentrations. To understand this effect, we present a theoretical simulation study of the reorientational motion of water molecules in different ionic solutions. Using an extended Ivanov model, water rotation is decomposed into contributions from large-amplitude angular jumps and a slower frame motion which was studied in a coarse-grained manner. Bearing a certain resemblance to water rotation near large biological molecules, the general deceleration is found to be largely due to the coupling of the slow, collective component of water rotation with the motion of large hydrated ion clusters ubiquitously existing in the concentrated ionic solutions. This finding is at variance with the intuitive expectation that the slowing down is caused by the change in fast, single-molecular water hydrogen bond switching adjacent to the ions.
PMID: 28874580

Shen J,Lai DH,Wilson RA,Chen YF,Wang LF,Yu ZL,Li MY,He P,Hide G,Sun X,Yang TB,Wu ZD,Ayala FJ,Lun ZR
Nitric oxide blocks the development of the human parasite Schistosoma japonicum.
Proc Natl Acad Sci U S A. 2017 Sep 05;
Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of morbidity is considered to be granulomas induced by fertilized eggs of schistosomes in the liver and intestines. Some host species, like rats (Rattus norvegicus), are naturally intolerant to Schistosoma japonicum infection, and do not produce granulomas or pose a threat to transmission, while others, like mice and hamsters, are highly susceptible. The reasons behind these differences are still a mystery. Using inducible nitric oxide synthase knockout (iNOS(-/-)) Sprague-Dawley rats, we found that inherent high expression levels of iNOS in wild-type (WT) rats play an important role in blocking growth, reproductive organ formation, and egg development in S. japonicum, resulting in production of nonfertilized eggs. Granuloma formation, induced by fertilized eggs in the liver, was considerably exacerbated in the iNOS(-/-) rats compared with the WT rats. This inhibition by nitric oxide acts by affecting mitochondrial respiration and energy production in the parasite. Our work not only elucidates the innate mechanism that blocks the development and production of fertilized eggs in S. japonicum but also offers insights into a better understanding of host-parasite interactions and drug development strategies against schistosomiasis.
PMID: 28874579

McConnell JR,Burke A,Dunbar NW,Khler P,Thomas JL,Arienzo MM,Chellman NJ,Maselli OJ,Sigl M,Adkins JF,Baggenstos D,Burkhart JF,Brook EJ,Buizert C,Cole-Dai J,Fudge TJ,Knorr G,Graf HF,Grieman MM,Iverson N,McGwire KC,Mulvaney R,Paris G,Rhodes RH,Saltzman ES,Severinghaus JP,Steffensen JP,Taylor KC,Winckler G
Synchronous volcanic eruptions and abrupt climate change ~17.7 ka plausibly linked by stratospheric ozone depletion.
Proc Natl Acad Sci U S A. 2017 Sep 05;
Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ~17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ~192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics-similar to those associated with modern stratospheric ozone depletion over Antarctica-plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ~17.7 ka.
PMID: 28874529

Presacco A,Simon JZ,Anderson S
Effect of informational content of noise on speech representation in the aging midbrain and cortex.
J Neurophysiol. 2016 Nov 01;116(5):2356-2367
The ability to understand speech is significantly degraded by aging, particularly in noisy environments. One way that older adults cope with this hearing difficulty is through the use of contextual cues. Several behavioral studies have shown that older adults are better at following a conversation when the target speech signal has high contextual content or when the background distractor is not meaningful. Specifically, older adults gain significant benefit in focusing on and understanding speech if the background is spoken by a talker in a language that is not comprehensible to them (i.e., a foreign language). To understand better the neural mechanisms underlying this benefit in older adults, we investigated aging effects on midbrain and cortical encoding of speech when in the presence of a single competing talker speaking in a language that is meaningful or meaningless to the listener (i.e., English vs. Dutch). Our results suggest that neural processing is strongly affected by the informational content of noise. Specifically, older listeners' cortical responses to the attended speech signal are less deteriorated when the competing speech signal is an incomprehensible language rather than when it is their native language. Conversely, temporal processing in the midbrain is affected by different backgrounds only during rapid changes in speech and only in younger listeners. Additionally, we found that cognitive decline is associated with an increase in cortical envelope tracking, suggesting an age-related over (or inefficient) use of cognitive resources that may explain their difficulty in processing speech targets while trying to ignore interfering noise.
PMID: 27605531

Presacco A,Simon JZ,Anderson S
Evidence of degraded representation of speech in noise, in the aging midbrain and cortex.
J Neurophysiol. 2016 Nov 01;116(5):2346-2355
Humans have a remarkable ability to track and understand speech in unfavorable conditions, such as in background noise, but speech understanding in noise does deteriorate with age. Results from several studies have shown that in younger adults, low-frequency auditory cortical activity reliably synchronizes to the speech envelope, even when the background noise is considerably louder than the speech signal. However, cortical speech processing may be limited by age-related decreases in the precision of neural synchronization in the midbrain. To understand better the neural mechanisms contributing to impaired speech perception in older adults, we investigated how aging affects midbrain and cortical encoding of speech when presented in quiet and in the presence of a single-competing talker. Our results suggest that central auditory temporal processing deficits in older adults manifest in both the midbrain and in the cortex. Specifically, midbrain frequency following responses to a speech syllable are more degraded in noise in older adults than in younger adults. This suggests a failure of the midbrain auditory mechanisms needed to compensate for the presence of a competing talker. Similarly, in cortical responses, older adults show larger reductions than younger adults in their ability to encode the speech envelope when a competing talker is added. Interestingly, older adults showed an exaggerated cortical representation of speech in both quiet and noise conditions, suggesting a possible imbalance between inhibitory and excitatory processes, or diminished network connectivity that may impair their ability to encode speech efficiently.
PMID: 27535374

Bauer J,Meza LR,Schaedler TA,Schwaiger R,Zheng X,Valdevit L
Nanolattices: An Emerging Class of Mechanical Metamaterials.
Adv Mater. 2017 Sep 05;
In 1903, Alexander Graham Bell developed a design principle to generate lightweight, mechanically robust lattice structures based on triangular cells; this has since found broad application in lightweight design. Over one hundred years later, the same principle is being used in the fabrication of nanolattice materials, namely lattice structures composed of nanoscale constituents. Taking advantage of the size-dependent properties typical of nanoparticles, nanowires, and thin films, nanolattices redefine the limits of the accessible material-property space throughout different disciplines. Herein, the exceptional mechanical performance of nanolattices, including their ultrahigh strength, damage tolerance, and stiffness, are reviewed, and their potential for multifunctional applications beyond mechanics is examined. The efficient integration of architecture and size-affected properties is key to further develop nanolattices. The introduction of a hierarchical architecture is an effective tool in enhancing mechanical properties, and the eventual goal of nanolattice design may be to replicate the intricate hierarchies and functionalities observed in biological materials. Additive manufacturing and self-assembly techniques enable lattice design at the nanoscale; the scaling-up of nanolattice fabrication is currently the major challenge to their widespread use in technological applications.
PMID: 28873250

Hashim PW,Cohen JL,Pompei DT,Goldenberg G
Topical cannabinoids in dermatology.
Cutis. 2017 Jul;100(1):50-52
Topical cannabinoids are increasingly utilized by dermatology patients for a range of disorders; however, the acceptance of these over-the-counter products has far outpaced scientific investigation into their safety and efficacy. Here, we review the studies of topical cannabinoids in skin conditions and assess their current place in dermatology practice.
PMID: 28873100

Chakravarthy B,Somasundaram S,Mogi J,Burns R,Hoonpongsimanont W,Wiechmann W,Lotfipour S
Randomized Pilot Trial Measuring Knowledge Acquisition of Opioid Education in Emergency Department Patients Using a Novel Media Platform.
Subst Abus. 2017 Sep 05;:0
The number of active opioid analgesic prescriptions has risen steadily causing increases in nonmedical opioid use, addiction and overdose. Insufficient focus on patient discharge instructions has contributed to lack of patient awareness regarding dangers of opioids. We examine whether an educational Khan Academy-styled animation discharge instruction on the dangers and safe usage of opioid analgesics elicits higher knowledge acquisition than current standard of care. Additionally, we measure the feasibility of implementing this video discharge instruction in the emergency department (ED).
PMID: 28873050

Inaba CS,Sujatha-Bhaskar S,Koh CY,Jafari MD,Mills SD,Carmichael JC,Stamos MJ,Pigazzi A
Robotic ventral mesh rectopexy for rectal prolapse: a single-institution experience.
Tech Coloproctol. 2017 Sep 04;
Robotic ventral mesh rectopexy (RVMR) is an appealing approach for the treatment of rectal prolapse and other conditions. The aim of this study was to evaluate the outcomes of RVMR for rectal prolapse.
PMID: 28871416

Qiu Y,Siwy Z
Probing charges on solid-liquid interfaces with the resistive-pulse technique.
Nanoscale. 2017 Sep 05;
Our manuscript addresses the issue of probing an effective surface charge that any surface can acquire at the solid/liquid interface. Even if a particle is predicted to be neutral based on its chemical structure, the particle can carry finite surface charges when placed in a solution. We present tools to probe the presence of surface charge densities of meso-particles, characterized with zeta potentials below 10 mV. The tools are based on the resistive-pulse technique, which uses single pores to probe properties of individual objects including molecules, particles, and cells. The presented experiments were performed with particles 280 and 400 nm in diameter and single pores with opening diameter tuned between ~ 200 nm and one micron. Surface charge properties were probed in two modes: (i) the passage of the particles through pores of diameters larger than the particles, as well as (ii) an approach curve of a particle to a pore that is smaller than the particle diameter. The curve in the latter mode has a biphasic character starting with a low-amplitude current decrease, followed by a current enhancement reaching an amplitude of ~10% of the baseline current. The current increase was long-lasting and stable, and shown to strongly depend on the particle surface charge density. The results are explained via voltage-modulation of ionic concentrations in the pore.
PMID: 28871289

Davtyan H,Zagorski K,Petrushina I,Kazarian K,Goldberg NRS,Petrosyan J,Blurton-Jones M,Masliah E,Cribbs DH,Agadjanyan MG,Ghochikyan A
MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.
Neurobiol Aging. 2017 Aug 10;
We have previously demonstrated that anti-beta amyloid DNA vaccine (AV-1959D) based on our proprietary MultiTEP platform technology is extremely immunogenic in mice, rabbits, and monkeys. Importantly, MultiTEP platform enables development of vaccines targeting pathological molecules involved in various neurodegenerative disorders. Taking advantage of the universality of MultiTEP platform, we developed DNA vaccines targeting 3 B-cell epitopes (amino acids [aa]85-99, aa109-126, and aa126-140) of human alpha-synuclein (ha-Syn) separately or all 3 epitopes simultaneously. All 4 DNA vaccines (1) generate high titers of anti-ha-Syn antibodies and (2) induce robust MultiTEP-specific T-helper cell responses without activation of potentially detrimental autoreactive anti-ha-Syn T-helper cells. Generated antibodies recognize misfolded ha-Syn produced by neuroblastoma cells, ha-Syn in the brain tissues of transgenic mouse strains and in the brain tissues of dementia with Lewy body cases. Based on these results, the most promising vaccine targeting 3 B-cell epitopes of ha-Syn simultaneously (PV-1950D) has been chosen for ongoing preclinical assessment in mouse models of ha-Syn with the aim to translate it to the human clinical trials.
PMID: 28870518

Tian Y,Ma X,Lv C,Sheng X,Li X,Zhao R,Song Y,Andl T,Plikus MV,Sun J,Ren F,Shuai J,Lengner CJ,Cui W,Yu Z
Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis.
Elife. 2017 Sep 05;6
Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration and tumorigenesis can help uncover the underlying principles of intestinal homeostasis and disease including colorectal cancer. Here we show that miR-31 drives ISC proliferation, and protects ISCs against apoptosis, both during homeostasis and regeneration in response to ionizing radiation injury. Furthermore, miR-31 has oncogenic properties, promoting intestinal tumorigenesis. Mechanistically, miR-31 acts to balance input from Wnt, BMP, TGF signals to coordinate control of intestinal homeostasis, regeneration and tumorigenesis. We further find that miR-31 is regulated by the STAT3 signaling pathway in response to radiation injury. These findings identify miR-31 as a critical modulator of ISC biology, and a potential therapeutic target for a broad range of intestinal regenerative disorders and cancers.
PMID: 28870287

Pierce J,Zhdanova L,Lucas T
Positive and negative affectivity, stress, and well-being in African-Americans: Initial demonstration of a polynomial regression and response surface methodology approach.
Psychol Health. 2017 Sep 05;:1-20
The extent to which positive (PA) and negative (NA) affect conjointly impact well-being is not yet well understood. Additionally, research investigating the role of affectivity in maintaining well-being among ethnic and racial minorities is scant. The current research demonstrates how polynomial regression and response surface methodology (PR and RSM) may be used to better understand how PA and NA jointly influence stress and well-being.
PMID: 28870108

Sayad A,Ibrahim F,Mukim Uddin S,Cho J,Madou M,Thong KL
A microdevice for rapid, monoplex and colorimetric detection of foodborne pathogens using a centrifugal microfluidic platform.
Biosens Bioelectron. 2017 Aug 31;100:96-104
Outbreaks of foodborne diseases have become a global health concern; hence, many improvements and developments have been made to reduce the risk of food contamination. We developed a centrifugal microfluidic automatic wireless endpoint detection system integrated with loop mediated isothermal amplification (LAMP) for monoplex pathogen detection. Six identical sets were designed on the microfluidic compact disc (CD) to perform 30 genetic analyses of three different species of foodborne pathogens. The consecutive loading, mixing, and aliquoting of the LAMP primers/reagents and DNA sample solutions were accomplished using an optimized square-wave microchannel, metering chambers and revulsion per minute (RPM) control. We tested 24 strains of pathogenic bacteria (Escherichia coli, Salmonella spp and Vibrio cholerae), with 8 strains of each bacterium, and performed DNA amplification on the microfluidic CD for 60min. Then, the amplicons of the LAMP reaction were detected using the calcein colorimetric method and further analysed via the developed electronic system interfaced with Bluetooth wireless technology to transmit the results to a smartphone. The system showed a limit of detection (LOD) of 3 10(-5)ngL(-1) DNA by analysing the colour change when tested with chicken meat spiked with the three pathogenic bacteria. Since the entire process was performed in a fully automated way and was easy to use, our microdevice is suitable for point-of-care (POC) testing with high simplicity, providing affordability and accessibility even to poor, resource-limited settings.
PMID: 28869845

Choi B,Ko S,Kojaku S
Resting heart rate, heart rate reserve, and metabolic syndrome in professional firefighters: A cross-sectional study.
Am J Ind Med. 2017 Sep 04;
Little is known about the associations of resting heart rate (RHR) and heart rate reserve (HRR) with metabolic syndrome (MetS) in firefighters.
PMID: 28869309

Brenner M,Azer SM,Oh KJ,Han CH,Lee J,Mahon SB,Du X,Mukai D,Burney T,Saidian M,Chan A,Straker DI,Bebarta VS,Boss GR
Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion.
J Clin Toxicol. 2017 Jun;7(3)
Accidental or intentional cyanide ingestion is an-ever present danger. Rapidly acting, safe, inexpensive oral cyanide antidotes are needed that can neutralize large gastrointestinal cyanide reservoirs. Since humans cannot be exposed to cyanide experimentally, we studied oral cyanide poisoning in rabbits, testing oral sodium thiosulfate with and without gastric alkalization.
PMID: 28868209

Kinney MC,Cidambi KR,Severns DL,Gonzales FB
Comparison of the iAssist Handheld Guidance System to Conventional Instruments for Mechanical Axis Restoration in Total Knee Arthroplasty.
J Arthroplasty. 2017 Jun 09;
Recent advances in total knee arthroplasty (TKA) include an intelligent instrument system designed to provide intraoperative guidance to reduce mechanical alignment errors. Internal position-sensing technology is integrated into microelectronic pods that attach to cutting blocks. The purpose of this prospective, randomized study was to determine whether this iAssist system enables the surgeon to make more accurate bone resections and better restore the mechanical axis compared to conventional instruments in TKA.
PMID: 28867520

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