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Adhikari B,Li J,Brandel MG,Futalan D,Akers J,Deming T,Chen CC,Carter BS
The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts.
J Clin Neurosci. 2017 Aug 31;
The current treatment of glioblastoma multiforme (GBM) is limited by the restricted arsenal of agents which effectively cross the blood brain barrier (BBB). For example, only a fraction of temozolomide (TMZ) administered systemically is available for therapeutic effect because of the BBB and the instability of TMZ under physiologic conditions. A novel approach to overcome this obstacle is to bypass the BBB and locally deliver chemotherapeutic agents directly to the tumor mass. We have explored the loading of TMZ into a novel hydrogel matrix, which can be delivered in liquid form and then solidifies in situ and releases chemotherapy as the matrix dissolves. Here, we tested the effect of amphiphilic diblock copolypeptide hydrogels (DCHs) of 180-poly-lysine and 20-poly-leucine (K180L20) on TMZ using Glioblastoma models. In both the in vitro model, which involved treatment of a human glioblastoma GSC line suspended as neurospheres, and in vivo using an orthotopic glioma xenograft mouse model, we found that K180L20 could safely enhance the efficacy of TMZ. This technique may offer the opportunity to 'coat' the inner lining of the cavity following glioma resection with a slow-release TMZ and potentially decrease recurrence. Future studies in larger animals are needed to delineate this effect.
PMID: 28867360

Inaba CS,Koh CY,Sujatha-Bhaskar S,Lee Y,Pejcinovska M,Nguyen NT
The effect of hospital teaching status on outcomes in bariatric surgery.
Surg Obes Relat Dis. 2017 Jul 20;
Studies have shown conflicting effects of resident involvement on outcomes after laparoscopic bariatric surgery. Resident involvement may be a proxy for a teaching environment in which multiple factors affect patient outcomes. However, no study has examined outcomes of laparoscopic bariatric surgery based on hospital teaching status.
PMID: 28867305

Baldwin JR,Arseneault L,Caspi A,Fisher HL,Moffitt TE,Odgers CL,Pariante C,Ambler A,Dove R,Kepa A,Matthews T,Menard A,Sugden K,Williams B,Danese A
Childhood Victimization and Inflammation in Young Adulthood: A Genetically Sensitive Cohort Study.
Brain Behav Immun. 2017 Aug 31;
Childhood victimization is an important risk factor for later immune-related disorders. Previous evidence has demonstrated that childhood victimization is associated with elevated levels of inflammation biomarkers measured decades after exposure. However, it is unclear whether this association is (1) already detectable in young people, (2) different in males and females, and (3) confounded by genetic liability to inflammation. Here we sought to address these questions.
PMID: 28867281

Bui TL,Silva-Hirschberg C,Torres J,Armstrong AW
Are patients comprehending? A critical assessment of online patient educational materials.
J Dermatolog Treat. 2017 Sep 04;:1-21
The primary aim of this study was to evaluate the readability, understandability, suitability, and actionability of online psoriasis patient educational materials. A secondary aim was to identify areas for improvement.
PMID: 28866954

Iwamoto DK,Corbin W,Takamatsu S,Castellanos J
The association between multidimensional feminine norms, binge drinking and alcohol-related problems among young adult college women.
Addict Behav. 2017 Aug 24;76:243-249
Alcohol consumption among women has steadily increased over the past 30years, and women's drinking behavior is now similar to that of men's. The escalation of alcohol use among women highlights the critical need to examine gender issues and motivational factors that contribute to binge drinking and related problems within this population. Feminine norms or the socially constructed beliefs, messages and attitudes about what it means to be a woman may contribute to within-group differences in drinking patterns among women. The current study examined the relationship between multidimensional feminine norms and binge drinking and alcohol-related problems among 1910 college women. Participants completed a self-report measure of binge drinking, alcohol-related problems, conformity to feminine norms, alcohol expectancies and descriptive norms. Controlling for the covariates descriptive norms, positive alcohol expectancies, and sorority membership, adherence to feminine norms related to sexual fidelity and belief that one needs to be sweet and nice were negatively associated to binge drinking, while adhering to investment in appearance was positively associated to binge drinking and alcohol-related problems. Distinct feminine norms also had a significant indirect effect on alcohol-related problems through binge drinking. This study significant contributes to the literature by elucidating the theoretically gender-relevant risk and protective aspects of feminine norms in relation to binge drinking and related problems, and provides important information that might be used in clinical and prevention efforts to reduce alcohol-related harm among a vulnerable group: college women.
PMID: 28865362

Minlikeeva AN,Freudenheim JL,Eng KH,Cannioto RA,Friel G,Szender JB,Segal B,Odunsi K,Mayor P,Diergaarde B,Zsiros E,Kelemen LE,Kbel M,Steed H,deFazio A,Jordan SJ,Fasching PA,Beckmann MW,Risch HA,Rossing MA,Doherty JA,Chang-Claude J,Goodman MT,Drk T,Edwards R,Modugno F,Ness RB,Matsuo K,Mizuno M,Karlan BY,Goode EL,Kjr SK,Hgdall E,Schildkraut JM,Terry KL,Cramer DW,Bandera EV,Paddock LE,Kiemeney LA,Massuger LFAG,Sutphen R,Anton-Culver H,Ziogas A,Menon U,Gayther SA,Ramus SJ,Gentry-Maharaj A,Pearce CL,Wu AH,Kupryjanczyk J,Jensen A,Webb PM,Moysich KB, ,
History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.
Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1470-1473
Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes.Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced).Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival.Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis. Cancer Epidemiol Biomarkers Prev; 26(9); 1470-3. 2017 AACR.
PMID: 28864456

Lacson JCA,Ma H,Lee E,Neuhausen SL,Anton-Culver H,Reynolds P,Nelson DO,Ziogas A,Van Den Berg D,Deapen DM,Bernstein L,Schumacher FR
Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study.
Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1462-1465
Background: Few studies have focused on the relationship of exonic variation with breast cancer and subtypes defined by tumor markers: estrogen receptor (ER), progesterone receptor (PR), and HER2.Methods: We genotyped 1,764 breast cancer patients and 1,400 controls from the California Teachers Study cohort using the Infinium HumanExome Beadchip. Individual variant and gene-based analyses were conducted for overall breast cancer and by individual tumor marker subtype.Results: No exonic variants or gene-based analyses were statistically significantly associated with breast cancer overall or by ER-, PR-, or HER2-defined subtype.Conclusions: We did not detect any novel statistically significant exonic variants with overall breast cancer risk or by subtype.Impact: Exonic variants in the exome chip may not be associated with overall breast cancer or subtype susceptibility. Cancer Epidemiol Biomarkers Prev; 26(9); 1462-5. 2017 AACR.
PMID: 28864454

Anderson WG,Puntillo K,Cimino J,Noort J,Pearson D,Boyle D,Grywalski M,Meyer J,O'Neil-Page E,Cain J,Herman H,Barbour S,Turner K,Moore E,Liao S,Ferrell B,Mitchell W,Edmonds K,Fairman N,Joseph D,MacMillan J,Milic MM,Miller M,Nakagawa L,O'Riordan DL,Pietras C,Thornberry K,Pantilat SZ
Palliative Care Professional Development for Critical Care Nurses: A Multicenter Program.
Am J Crit Care. 2017 Sep;26(5):361-371
Integrating palliative care into intensive care units (ICUs) requires involvement of bedside nurses, who report inadequate education in palliative care.
PMID: 28864431

Adams TNG,Jiang AYL,Vyas PD,Flanagan LA
Separation of Neural Stem Cells by Whole Cell Membrane Capacitance using Dielectrophoresis.
Methods. 2017 Aug 29;
Whole cell membrane capacitance is an electrophysiological property of the plasma membrane that serves as a biomarker for stem cell fate potential. Neural stem and progenitor cells (NSPCs) that differ in ability to form neurons or astrocytes are distinguished by membrane capacitance measured by dielectrophoresis (DEP). Differences in membrane capacitance are sufficient to enable the enrichment of neuron- or astrocyte-forming cells by DEP, showing the separation of stem cells on the basis of fate potential by membrane capacitance. NSPCs sorted by DEP need not be labeled and do not experience toxic effects from the sorting procedure. Other stem cell populations also display shifts in membrane capacitance as cells differentiate to a particular fate, clarifying the value of sorting a variety of stem cell types by capacitance. Here, we describe methods developed by our lab for separating NSPCs on the basis of capacitance using several types of DEP microfluidic devices, providing basic information on the sorting procedure as well as specific advantages and disadvantages of each device.
PMID: 28864355

Purdy AC,Idriss A,Ahern S,Lin E,Elfenbein DM
Dr Google: The readability and accuracy of patient education websites for Graves' disease treatment.
Surgery. 2017 Aug 29;
National guidelines emphasize the importance of incorporating patient preferences into the recommendations for the treatment of Graves' disease. Many patients use the Internet to obtain health information, and search results can affect their treatment decisions. This study compares the readability and accuracy of patient-oriented online resources for the treatment of Graves' disease by website affiliation and treatment modality.
PMID: 28864099

Lantis Ii JC,Gordon I
Clostridial Collagenase for the Management of Diabetic Foot Ulcers: Results of Four Randomized Controlled Trials.
Wounds. 2017 Aug 25;
Despite major treatment advances, diabetic foot ulcers (DFUs) remain a frequent and debilitating complication of diabetes mellitus and a major cause of significant morbidity and mortality.
PMID: 28862974

Arnold SV,Goyal A,Inzucchi SE,McGuire DK,Tang F,Mehta SN,Sperling LS,Maddox TM,Einhorn D,Wong ND,Hammar N,Fenici P,Khunti K,Lam CSP,Kosiborod M
Quality of Care of the Initial Patient Cohort of the Diabetes Collaborative Registry().
J Am Heart Assoc. 2017 Aug 11;6(8)
Although guidelines and performance measures exist for patients with diabetes mellitus, achievement of these metrics is not well known. The Diabetes Collaborative Registry() (DCR) was formed to understand the quality of diabetes mellitus care across the primary and specialty care continuum in the United States.
PMID: 28862933

Nasser S,Kyrgiou M,Krell J,Haidopoulos D,Bristow R,Fotopoulou C
A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries.
Ann Surg Oncol. 2017 Aug 31;
The aim of this study was to review the surgical and clinical outcomes of intrathoracic and mediastinal surgical cytoreduction in stage IV epithelial ovarian cancer (EOC). Relevant articles were identified from MEDLINE and EMBASE. Only analyses or reports that described actual intrathoracic cytoreduction via pleurectomy and/or resection of cardiophrenic/mediastinal lymph nodes were included. Imaging articles that merely described thoracic tumor patterns were excluded. A total of nine studies were identified, the oldest originating in 2007. Procedures described were transdiaphragmatic resection of cardiophrenic lymph nodes and pleural disease (n=5) and video-assisted thoracoscopic and mediastinal tumorectomies including pleurectomy (n=4). The number of operated patients ranged between 1 and 30 with complete cytoreduction rates ranging between 68 and 100%. No surgical deaths directly related to the thoracic cytoreduction were reported and only one patient (1/30) experienced a postoperative complication in terms of a pneumothorax. None of the studies presented a direct comparison of survival to patients with thoracic disease who did not undergo thoracic cytoreduction, and therefore the survival benefit of thoracic cytoreduction could not be quantified. In conclusion, thoracic cytoreduction in advanced EOC seems feasible and with acceptable morbidity while offering a better understanding of the extent of disease and hence allowing the tailoring of intraabdominal resections. Nevertheless, its direct impact on patients' survival by a potential overruling of a more adverse tumor biology remains to be established in larger-scale prospective and ideally randomized trials.
PMID: 28861808

Piomelli D,Cooper Z,Abrams D,Grant I,Patel S
A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members.
Cannabis Cannabinoid Res. 2017;2(1):155-159
PMID: 28861515

Angelini R,Argueta DA,Piomelli D,DiPatrizio NV
Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware.
Cannabis Cannabinoid Res. 2017;2(1):123-132
Introduction: Fatty acid ethanolamides (FAEs) are a family of lipid mediators that participate in a host of biological functions. Procedures for the quantitative analysis of FAEs include organic solvent extraction from biological matrices (e.g., blood), followed by purification and subsequent quantitation by liquid chromatography-mass spectrometry (LC/MS) or gas chromatography-mass spectrometry. During the validation process of a new method for LC/MS analysis of FAEs in biological samples, we observed unusually high levels of the FAE, palmitoylethanolamide (PEA), in blank samples that did not contain any biological material. Materials and Methods: We investigated a possible source of this PEA artifact via liquid chromatography coupled to tandem mass spectrometry, as well as accurate mass analysis. Results: We found that high levels of a contaminant indistinguishable from PEA is present in new 5.75? glass Pasteur pipettes, which are routinely used by laboratories to carry out lipid extractions. This artifact might account for discrepancies found in the literature regarding PEA levels in human blood serum and other tissues. Conclusions: It is recommended to take into account this pitfall by analyzing potential contamination of the disposable glassware during the validation process of any method used for analysis of FAEs.
PMID: 28861512

Moradi H,Oveisi F,Khanifar E,Moreno-Sanz G,Vaziri ND,Piomelli D
Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury.
Cannabis Cannabinoid Res. 2016;1(1):218-228
Background: Acute kidney injury (AKI) is associated with a significantly increased risk of morbidity and mortality. Ischemia-reperfusion injury (IRI) is a major cause of AKI. In this study, we investigated the role of the endocannabinoid (EC) system in renal IRI using a well-established mouse model. Materials and Methods: Renal ischemia was induced in male C57BL/6 mice by clamping both kidney pedicles for 30?min followed by 24?h of reperfusion. To increase renal 2-arachidonoylglycerol (2-AG) levels, mice were pretreated with JZL184 (16?mg/kg), 30?min before IRI. Serum creatinine and blood urea nitrogen (BUN), renal tubular damage, renal content of ECs and renal expression of markers of inflammation and oxidative stress were measured. Results: Renal IRI was associated with significantly increased serum BUN and creatinine, increased tubular damage score, increased expression of renal markers of inflammation and oxidative stress and elevated renal 2-AG content. Pretreatment with JZL184 was associated with a significant increase in renal 2-AG content and there was also improved serum BUN, creatinine and tubular damage score. However, renal expression of inflammation and oxidative stress markers remained unchanged. Conclusions: This is the first report documenting that renal IRI is associated with an increase in kidney 2-AG content. Further enhancement of 2-AG levels using JZL184 improved indices of renal function and histology, but did not lower renal expression of markers of inflammation and oxidative stress. Further studies are needed to determine the mechanisms responsible for the effects observed and the potential value of 2-AG as a therapeutic target in renal IRI.
PMID: 28861493

Hinkle P,Westerhof TM,Qiu Y,Mallin DJ,Wallace ML,Nelson EL,Taborek P,Siwy ZS
A hybrid resistive pulse-optical detection platform for microfluidic experiments.
Sci Rep. 2017 Aug 31;7(1):10173
Resistive-pulse sensing is a label-free method for characterizing individual particles as they pass through ion-conducting channels or pores. During a resistive pulse experiment, the ionic current through a conducting channel is monitored as particles suspended in the solution translocate through the channel. The amplitude of the current decrease during a translocation, or 'pulse', depends not only on the ratio of the particle and channel sizes, but also on the particle position, which is difficult to resolve with the resistive pulse signal alone. We present experiments of simultaneous electrical and optical detection of particles passing through microfluidic channels to resolve the positional dependencies of the resistive pulses. Particles were tracked simultaneously in the two signals to create a mapping of the particle position to resistive pulse amplitude at the same instant in time. The hybrid approach will improve the accuracy of object characterization and will pave the way for observing dynamic changes of the objects such as deformation or change in orientation. This combined approach of optical detection and resistive pulse sensing will join with other attempts at hybridizing high-throughput detection techniques such as imaging flow cytometry.
PMID: 28860641

Silva HM
Intelligent design endangers education.
Science. 2017 Sep 01;357(6354):880
PMID: 28860376

Morrissette NS,Goulding CW
From B to A: making an essential cofactor in a human parasite.
Biochem J. 2017 Aug 30;474(18):3089-3092
Trypanosomatids are parasitic eukaryotic organisms that cause human disease. These organisms have complex lifestyles; cycling between vertebrate and insect hosts and alternating between two morphologies; a replicating form and an infective, nonreplicating one. Because trypanosomatids are one of the few organisms that do not synthesize the essential cofactor, heme, these parasites sequester the most common form, heme B, from their hosts. Once acquired, the parasites derivatize heme B to heme A by two sequential enzyme reactions. Although heme C is found in many cytochrome c and c1 proteins, heme A is the cofactor of only one known protein, cytochrome c oxidase (CcO). In a recent issue of the Biochemical Journal, Merli et al. [Biochem. J. (2017) 474, 2315-2332] demonstrate that the final step in the synthesis of heme A by heme A synthase (TcCox15) and the subsequent activity of CcO are essential for infectivity and replication of Trypanosoma cruzi.
PMID: 28860337

Ma KW,Yao DH,Li Y,Li GD,Cherukury H,Jing AH,Liang GF
Synergistic Effects of Polymer Adsorbents on the Performance of Bilirubin Hemoperfusion.
J Biomater Sci Polym Ed. 2017 Sep 01;:1-12
Neonatal hyperbilirubinemia (jaundice) is a common disease with high incidence. Currently, the clinical inefficiency of adult bilirubin hemoperfusion medical adsorbent is a major technical barrier for the application of hemoperfusion treatment to rescue the severe neonatal jaundice. Based on the well-known principle of synergistic effects, a series of customized bilirubin polymeric compounds, comprised of one or more of the following components (glycidyl methacrylate, sodium acrylate, methacrylic acid isooctyl, hexamethylene diamine, albumin), were designed and fabricated based on molecular design. Their adsorption performances upon bilirubin were investigated and compared under the same conditions, and the compound with the highest adsorption performance was then subject to preliliminary safety assessments and compared with a commercial one (BS330). The results showed that positive synergistic effects appeared on the adsorption performance to adsorb bilirubin based on this study, and the one comprised of glycidyl methacrylate+sodium acrylate+methacrylic acid isoocty+hexamethylene diamine+albumin possesses the highest adsorption performance as well as outome clinical acceptable medical safety assessments, and its adsorption efficiency was up to 46% while the commerical one's was about 26% under the same conditions. This study sheds a new light on how to design and develop hemoperfusion bilirubin adsorbents with good overall clinical performance, as well as providing a novel idea and experimental referrences for future related topics.
PMID: 28859538

Williams S,Morales B,Huynh LM,Osann KE,Skarecky D,Ahlering T
Analysis of Accessory Pudendal Artery Transection on Erections during Robot-Assisted Radical Prostatectomy (RARP).
J Endourol. 2017 Aug 31;
To compare the recovery of erections and potency following the transection of APAs in men undergoing robot-assisted radical prostatectomy (RARP) as compared to men with normal vascular anatomy.
PMID: 28859491

Jabbour E,Ravandi F,Kebriaei P,Huang X,Short NJ,Thomas D,Sasaki K,Rytting M,Jain N,Konopleva M,Garcia-Manero G,Champlin R,Marin D,Kadia T,Cortes J,Estrov Z,Takahashi K,Patel Y,Khouri MR,Jacob J,Garris R,O'Brien S,Kantarjian H
Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini-Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Phase 2 Clinical Trial.
JAMA Oncol. 2017 Aug 31;
The outcome of patients with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) is poor. Inotuzumab ozogamicin, a CD22 monoclonal antibody bound to calicheamicin, has single-agent activity in R/R ALL.
PMID: 28859185

Buchbinder DK,Fortier MA,Osann K,Wilford J,Shen V,Torno L,Sender LS,Parsons SK,Wenzel L
Quality of Life Among Parents of Adolescent and Young Adult Brain Tumor Survivors.
J Pediatr Hematol Oncol. 2017 Aug 30;
We aimed to describe the quality of life (QOL) among parents of adolescent and young adult brain tumor survivors as well as parent, survivor, and diagnosis/treatment-related factors associated with adverse QOL. A cross-sectional study of 28 parents of adolescent and young adult brain tumor survivors (who were on average 10?y postdiagnosis) was used to assess QOL. Parent QOL was measured using the Patient-Reported Outcomes Measurement Information System Global Health measure. Factors associated with adverse parent QOL were explored using logistic regression including: parent, survivor, and diagnosis/treatment-related factors. Parent QOL was within the normal range; however, 40% scored below the clinical threshold of 0.5?SD below the mean for physical and mental health. Parent perceptions of greater family impact, survivor emotional/behavioral health problems, improved cognitive function, and recurrence were associated with adverse parent physical health. Parent anger/sorrow, uncertainty, survivor emotional/behavioral health problems, speech/language problems, and recurrence were associated with adverse parent mental health. Parental emotional resources and perceptions of improved survivor peer relationships were associated with greater parent physical and mental health. The impact of a brain tumor diagnosis and treatment on the QOL of parents may be significant. Interventions are needed to ensure that the needs of parents are met.
PMID: 28859042

Yu J,Ravel VA,You AS,Streja E,Rivara MB,Potukuchi PK,Brunelli SM,Kovesdy CP,Kalantar-Zadeh K,Rhee CM
Association between Testosterone and Mortality Risk among U.S. Males Receiving Dialysis.
Am J Nephrol. 2017 Sep 01;46(3):195-203
Among the general population, low circulating testosterone levels are associated with higher risk of cardiovascular disease and death. While testosterone deficiency is common in dialysis patients, studies of testosterone and mortality in this population are ambiguous and overlapping. We hypothesized that lower testosterone levels are associated with higher mortality in male dialysis patients.
PMID: 28858868

Ramaswamy S,Driscoll D,Reist C,Smith LM,Albers LJ,Rose J,Nguyen L,Monga V,Doria R,Hollifield M
A Double-Blind, Placebo-Controlled Randomized Trial of Vilazodone in the Treatment of Posttraumatic Stress Disorder and Comorbid Depression.
Prim Care Companion CNS Disord. 2017 Aug 24;19(4)
To determine the efficacy, safety, and tolerability of vilazodone in the treatment of posttraumatic stress disorder (PTSD) with comorbid mild-to-moderate depression.
PMID: 28858440

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