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Microfluidic device for rapid digestion of tissues into cellular suspensions.
Lab Chip. 2017 Aug 29;
The ability to harvest single cells from tissues is currently a bottleneck for cell-based diagnostic technologies, and remains crucial in the fields of tissue engineering and regenerative medicine. Tissues are typically broken down using proteolytic digestion and various mechanical treatments, but success has been limited due to long processing times, low yield, and high manual labor burden. Here, we present a novel microfluidic device that utilizes precision fluid flows to improve the speed and efficiency of tissue digestion. The microfluidic channels were designed to apply hydrodynamic shear forces at discrete locations on tissue specimens up to 1 cm in length and 1 mm in diameter, thereby accelerating digestion through hydrodynamic shear forces and improved enzyme-tissue contact. We show using animal organs that our digestion device with hydro-mincing capabilities was superior to conventional scalpel mincing and digestion based on recovery of DNA and viable single cells. Thus, our microfluidic digestion device can eliminate or reduce the need to mince tissue samples with a scalpel, while reducing sample processing time and preserving cell viability. Another advantage is that downstream microfluidic operations could be integrated to enable advanced cell processing and analysis capabilities. We envision our novel device being used in research and clinical settings to promote single cell-based analysis technologies, as well as to isolate primary, progenitor, and stem cells for use in the fields of tissue engineering and regenerative medicine.
Willard KS,Sullivan JB,Thomashow BM,Jones CS,Fromer L,Yawn BP,Amin A,Rommes JM,Rotert R
The 2nd National COPD Readmissions Summit and Beyond: From Theory to Implementation.
Chronic Obstr Pulm Dis. 2016 Oct 06;3(4):778-790
Chronic obstructive pulmonary disease (COPD) hospitalizations and readmissions adversely impact the health and quality of life of COPD patients. Under the Hospital Readmissions Reduction Program, the Centers for Medicare & Medicaid Services reduce payments to those hospitals exceeding expected rates of COPD readmissions within 30 days of hospital discharge. It was within this climate that the COPD Foundation held its 2(nd) COPD Readmissions Summit in March 2015. Experts in attendance: (1) categorized challenges to optimal COPD care, ( 2) analyzed the state of care delivery and readmissions reduction strategies and (3) identified the best available evidence-based approaches to improving care delivery across the continuum, including early diagnosis via spirometry, ongoing device, oxygen and medication reconciliation, treatment that addresses comorbidities and preventive care, robust patient education, prompt post-acute follow up, home health services and pulmonary rehabilitation. Results of this collaborative event formed the basis for PRAXIS, the COPD Foundation's initiative to improve COPD care across the health continuum and to reduce readmissions.
Moftakhari HR,Salvadori G,AghaKouchak A,Sanders BF,Matthew RA
Compounding effects of sea level rise and fluvial flooding.
Proc Natl Acad Sci U S A. 2017 Aug 28;
Sea level rise (SLR), a well-documented and urgent aspect of anthropogenic global warming, threatens population and assets located in low-lying coastal regions all around the world. Common flood hazard assessment practices typically account for one driver at a time (e.g., either fluvial flooding only or ocean flooding only), whereas coastal cities vulnerable to SLR are at risk for flooding from multiple drivers (e.g., extreme coastal high tide, storm surge, and river flow). Here, we propose a bivariate flood hazard assessment approach that accounts for compound flooding from river flow and coastal water level, and we show that a univariate approach may not appropriately characterize the flood hazard if there are compounding effects. Using copulas and bivariate dependence analysis, we also quantify the increases in failure probabilities for 2030 and 2050 caused by SLR under representative concentration pathways 4.5 and 8.5. Additionally, the increase in failure probability is shown to be strongly affected by compounding effects. The proposed failure probability method offers an innovative tool for assessing compounding flood hazards in a warming climate.
Budoff MJ,Mayrhofer T,Ferencik M,Bittner DO,Lee KL,Lu MT,Coles A,Jang JJ,Krishnam MS,Douglas PS,Hoffmann U,
The Prognostic Value of Coronary Artery Calcium in the PROMISE Study.
Circulation. 2017 Aug 28;
Background -Coronary artery calcium (CAC) is an established predictor of future major adverse atherosclerotic cardiovascular events in asymptomatic individuals. However limited data exist as to how CAC compares to functional testing (FT) in estimating prognosis in symptomatic patients. Methods -In the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial, patients with stable chest pain (or dyspnea) and intermediate pre-test probability for obstructive coronary artery disease (CAD) were randomized to FT (exercise electrocardiography, nuclear stress, or stress echocardiography) or anatomic testing. We evaluated those who underwent CAC testing as part of the anatomic evaluation (n=4,209) and compared to results of FT (n=4,602). We stratified CAC and FT results as normal or mildly, moderately or severely abnormal (for CAC: 0, 1-99 Agatston Score [AS], 100-400 AS and >400 AS, respectively; for FT: normal, mild=late positive treadmill, moderate=early positive treadmill or single-vessel ischemia and severe=large ischemic region abnormality). The primary endpoint was all-cause death, myocardial infarction or unstable angina hospitalization over a median follow-up of 26.1 months. Cox regression models were used to calculate hazard ratios and C-statistic to determine predictive and discriminatory value. Results - Overall, the distribution of normal or mildly, moderately or severely abnormal test results was significantly different between FT and CAC (FT = normal 3588 [78.0%], mild 432 [9.4%], moderate 217 [4.7%], severe 365 [7.9%]; CAC = normal 1,457 [34.6%], mild 1340 [31.8%], moderate 772 [18.3%], severe 640 [15.2%], p 0) whereas less than half of events occurred in patients with mild, moderate or severely abnormal FT (n=57/132; 43%) (p
Asayama K,Li Y,Franklin SS,Thijs L,O'Brien E,Staessen JA
Cardiovascular Risk Associated With White Coat Hypertension: Con Side of the Argument.
Hypertension. 2017 Aug 28;
Nguyen HX,Hooshmand MJ,Saiwai H,Maddox J,Salehi A,Lakatos A,Nishi R,Salazar D,Uchida N,Anderson AJ
Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair.
J Neurosci. 2017 Aug 28;
The interaction of transplanted stem cells with local cellular and molecular cues in the host central nervous system (CNS) microenvironment may affect the potential for repair by therapeutic cell populations. In this regard, spinal cord injury (SCI), Alzheimer's disease, and other neurological injuries and diseases all exhibit dramatic and dynamic changes to the host microenvironment over time. Previously, we reported that delayed transplantation of CNS-derived human neural stem cells (hCNS-SCns) at 9 or 30 days post-SCI (dpi) resulted in extensive donor cell migration, predominantly neuronal and oligodendrocytic donor cell differentiation, and functional locomotor improvements. Here, we report that acute transplantation of hCNS-SCns at 0 dpi resulted in localized astroglial differentiation of donor cells near the lesion epicenter, and failure to produce functional improvement in an all-female immunodeficient mouse model. Critically, specific immunodepletion of neutrophils (polymorphonuclear leukocytes, PMN) blocked hCNS-SCns astroglial differentiation near the lesion epicenter and rescued the capacity of these cells to restore function. These data represent novel evidence that a host immune cell population can block the potential for functional repair derived from a therapeutic donor cell population, and support targeting the inflammatory microenvironment in combination with cell transplantation after SCI.SIGNIFICANCE STATEMENTThe interaction of transplanted cells with local cellular and molecular cues in the host microenvironment is a key variable that may shape the translation of neurotransplantation research to the clinical SCI human population, and few studies have investigated these events. We show that the specific immunodepletion of PMN neutrophils using anti-Ly6G inhibits donor cell astrogliosis and rescues the capacity of a donor cell population to promote locomotor improvement after SCI. Critically, our data demonstrate novel evidence that a specific host immune cell population can block the potential for functional repair derived from a therapeutic donor cell population.
Makowski MJ,Galhenage RP,Langford J,Hemminger JC
Liquid-Jet X-ray Photoelectron Spectra of TiO(2) Nanoparticles in an Aqueous Electrolyte Solution.
J Phys Chem Lett. 2016 05 05;7(9):1732-5
Titania has attracted significant interest due to its broad catalytic applications, many of which involve titania nanoparticles in contact with aqueous electrolyte solutions. Understanding the titania nanoparticle/electrolyte interface is critical for the rational development of such systems. Here, we have employed liquid-jet ambient pressure X-ray photoelectron spectroscopy (AP-XPS) to investigate the solid/electrolyte interface of 20 nm diameter TiO2 nanoparticles in 0.1 M aqueous nitric acid solution. The Ti 2p line shape and absolute binding energy reflect a fully oxidized stoichiometric titania lattice. Further, by increasing the X-ray excitation energy, the difference in O 1s binding energies between that of liquid water (O 1sliq) and the titania lattice (O 1slat) oxygen was measured as a function of probe depth into the particles. The titania lattice, O 1slat, binding energy decreases by 250 meV when probing from the particle surface into the bulk. This is interpreted as downward band bending at the interface.
Mao SS,Li D,Syed YS,Gao Y,Luo Y,Flores F,Child J,Cervantes M,Kalantar-Zadeh K,Budoff MJ
Thoracic Quantitative Computed Tomography (QCT) Can Sensitively Monitor Bone Mineral Metabolism: Comparison of Thoracic QCT vs Lumbar QCT and Dual-energy X-ray Absorptiometry in Detection of Age-relative Change in Bone Mineral Density.
Acad Radiol. 2017 Aug 22;
Sensitive detection of bone mineral density (BMD) change is a key issue to monitor and evaluate the individual bone health status, as well as bone metabolism and bone mineral status. The ability to use thoracic quantitative computed tomography (QCT) to detect the annual change of BMD remains unclear. We aimed to investigate the sensitivity in detecting age-related bone mineral loss using the thoracic QCT from the electrocardiographically gated heart scans in comparison to whole-body dual-energy X-ray absorptiometry (DXA) and standard lumbar QCT.
Chen Y,Capponi S,Zhu L,Gellenbeck P,Freites JA,White SH,Dalbey RE
YidC Insertase of Escherichia coli: Water Accessibility and Membrane Shaping.
Structure. 2017 Aug 08;
The YidC/Oxa1/Alb3 family of membrane proteins function to insert proteins into membranes in bacteria, mitochondria, and chloroplasts. Recent X-ray structures of YidC from Bacillus halodurans and Escherichia coli revealed a hydrophilic groove that is accessible from the lipid bilayer and the cytoplasm. Here, we explore the water accessibility within the conserved core region of the E. coli YidC using in vivo cysteine alkylation scanning and molecular dynamics (MD) simulations of YidC in POPE/POPG membranes. As expected from the structure, YidC possesses an aqueous membrane cavity localized to the membrane inner leaflet. Both the scanning data and the MD simulations show that the lipid-exposed transmembrane helices 3, 4, and 5 are short, leading to membrane thinning around YidC. Close examination of the MD data reveals previously unrecognized structural features that are likely important for protein stability and function.
Ahluwalia A,Jones MK,Hoa N,Tarnawski AS
NGF protects endothelial cells from indomethacin-induced injury through activation of mitochondria and upregulation of IGF-1.
Cell Signal. 2017 Aug 23;
Endothelial cells (ECs) lining blood vessels are critical for delivery of oxygen and nutrients to all tissues and organs and play a crucial role in the regeneration of blood vessel following tissue injury. ECs are also major targets of injury by a variety of noxious factors [e.g., ethanol and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, diclofenac], especially in gastric mucosa that has direct exposure to these agents. In this study, we investigated whether nerve growth factor (NGF) can protect gastric microvascular ECs (GECs) from injury by indomethacin (INDO) and the mechanisms involved.
Santos PJF,Daar DA,Badeau A,Leis A
Readability of online materials for Dupuytren's contracture.
J Hand Ther. 2017 Aug 23;
Juo YY,Mantha A,Abiri A,Lin A,Dutson E
Diffusion of robotic-assisted laparoscopic technology across specialties: a national study from 2008 to 2013.
Surg Endosc. 2017 Aug 25;
Robotic-assisted procedures were frequently found to have similar outcomes and indications to their laparoscopic counterparts, yet significant variation existed in the acceptance of robotic-assisted technology between surgical specialties and procedures. We performed a retrospective cohort study investigating factors associated with the adoption of robotic assistance across the United States from 2008 to 2013.
Yoshimura RF,Tran MB,Hogenkamp DJ,Ayala NL,Johnstone T,Dunnigan AJ,Gee TK,Gee KW
Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model.
Neuropharmacology. 2017 Aug 22;
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acidA (GABAA) and α7 nicotinic acetylcholine receptors (nAChRs) significantly impact E/I. BTBR T(+)tf/J (BTBR) mice are a model that display an autism-like phenotype with impaired social interaction and stereotyped behavior. A β2/3-subunit containing GABAA receptor (GABAAR) subtype selective positive allosteric modulator (PAM), 2-261, and an α7 nAChR subtype selective PAM, AVL-3288, were tested in social approach and repetitive self-grooming paradigms. 2-261 was active in the social approach but not the self-grooming paradigm, whereas AVL-3288 was active in both. Neither compound impaired locomotor activity. Modulating α7 nAChRs alone may be sufficient to correct these behavioral and cognitive deficits. GABAergic and nicotinic compounds are already in various stages of clinical testing for treatment of the core symptoms and comorbidities associated with ASD. Our findings and those of others suggest that compounds that have selective activities at GABAAR subtypes and the α7 nAChR may address not only the core symptoms, but many of the associated comorbidities as well and warrant further investigation in other models of ASD.
Thomas NE,Edmiston SN,Kanetsky PA,Busam KJ,Kricker A,Armstrong BK,Cust AE,Anton-Culver H,Gruber SB,Luo L,Orlow I,Reiner AS,Gallagher RP,Zanetti R,Rosso S,Sacchetto L,Dwyer T,Parrish EA,Hao H,Gibbs DC,Frank JS,Ollila DW,Begg CB,Berwick M,Conway K,
Associations of MC1R genotype and patient phenotypes with BRAF and NRAS mutations in melanoma.
J Invest Dermatol. 2017 Aug 22;
Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1227 participants in the international population-based Genes, Environment and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF+ were associated with younger age, blond/light brown hair, increased nevi, and less freckling and NRAS+ with older age relative to WT (BRAF-/NRAS-) melanomas (all P
Moog NK,Entringer S,Rasmussen JM,Styner M,Gilmore JH,Kathmann N,Heim CM,Wadhwa PD,Buss C
Intergenerational Effect of Maternal Exposure to Childhood Maltreatment on Newborn Brain Anatomy.
Biol Psychiatry. 2017 Jul 21;
Childhood maltreatment (CM) confers deleterious long-term consequences, and growing evidence suggests some of these effects may be transmitted across generations. We examined the intergenerational effect of maternal CM exposure on child brain structure and also addressed the hypothesis that this effect may start during the child's intrauterine period of life.
Yamaki T,de Haas HJ,Tahara N,Petrov A,Mohar D,Haider N,Zhou J,Tahara A,Takeishi Y,Boersma HH,Scarabelli T,Kini A,Strauss HW,Narula J
Cardioprotection by minocycline in a rabbit model of ischemia/reperfusion injury: Detection of cell death by in vivo (111)In-GSAO SPECT.
J Nucl Cardiol. 2017 Aug 24;
Preclinical studies indicate that minocycline protects against myocardial ischemia/reperfusion injury. In these studies, minocycline was administered before ischemia, which can rarely occur in clinical practice. The current study aimed to evaluate cardioprotection by minocycline treatment upon reperfusion.
Cao Y,Matsubara T,Zhao C,Gao W,Peng L,Shan J,Liu Z,Yuan F,Tang L,Li P,Guan Z,Fang Z,Lu X,Huang H,Yang Q
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment.
Sci Rep. 2017 Aug 24;7(1):9307
Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 conjugates for obesity treatment. ASOs primarily target fat and liver with poor penetrance to other organs. Pharmacological T3 treatment increases energy expenditure and causes weight loss, but is contraindicated for obesity treatment due to systemic effects on multiple organs. We hypothesize that ASO-T3 conjugates may knock down target genes and enrich T3 action in fat and liver. Two established ASOs are tested. Nicotinamide N-methyltransferase (NNMT)-ASO prevents diet-induced obesity in mice. Apolipoprotein B (ApoB)-ASO is an FDA approved drug for treating familial hypercholesterolemia. NNMT-ASO and ApoB-ASO are chemically conjugated with T3 using a non-cleavable sulfo-SMCC linker. Both NNMT-ASO-T3 (NAT3) and ApoB-ASO-T3 (AAT3) enhance thyroid hormone receptor activity. Treating obese mice with NAT3 or AAT3 decreases adiposity and increases lean mass. ASO-T3 enhances white fat browning, decreases genes for fatty acid synthesis in liver, and shows limited effects on T3 target genes in heart and muscle. Furthermore, AAT3 augments LDL cholesterol-lowering effects of ApoB-ASO. Therefore, ASO and hormone/drug conjugation may provide a novel strategy for obesity and hyperlipidemia treatment.
Wodarz D,Rodriguez-Brenes I
Early Stochastic Dynamics in Human Cytomegalovirus Infection.
J Virol. 2017 Sep 15;91(18)
Siwy Z,Fornasiero F
Improving on aquaporins.
Science. 2017 Aug 25;357(6353):753
Oztan A,Fischer S,Schrock AB,Erlich RL,Lovly CM,Stephens PJ,Ross JS,Miller V,Ali SM,Ou SI,Raez LE
Emergence of EGFR G724S mutation in EGFR-mutant lung adenocarcinoma post progression on osimertinib.
Lung Cancer. 2017 Sep;111:84-87
Mutations in the epidermal growth factor receptor (EGFR) are drivers for a subset of lung cancers. Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) recently approved for the treatment of T790M-positive non-small cell lung cancer (NSCLC); however, acquired resistance to osimertinib is evident and resistance mechanisms remain incompletely defined. The EGFR G724S mutation was detected using hybrid-capture based comprehensive genomic profiling (CGP) and a hybrid-capture based circulating tumor DNA (ctDNA) assays in two cases of EGFR-driven lung adenocarcinoma in patients who had progressed on osimertinib treatment. This study demonstrates the importance of both tissue and blood based hybrid-capture based genomic profiling at disease progression to identifying novel resistance mechanisms in the clinic.
Ou SI,Horn L,Cruz M,Vafai D,Lovly CM,Spradlin A,Williamson MJ,Dagogo-Jack I,Johnson A,Miller VA,Gadgeel S,Ali SM,Schrock AB
Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients.
Lung Cancer. 2017 Sep;111:61-64
Resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) with activating EGFR mutations generally involve development of acquired secondary or tertiary EGFR mutations, such as T790M or C797S. However, case reports have demonstrated that actionable receptor tyrosine kinase fusions such as EML4-ALK, CCDC6-RET, and FGFR3-TACC3 can potentially confer resistance to EGFR TKIs. We seeked to identify the prevalence of FGFR3-TACC3 fusion transcripts as resistance mechanism to EGFR TKIs. Hybrid-capture based genomic profiling was performed on FFPE tissue samples and circulating tumor DNA isolated from peripheral whole blood in the course of clinical care. We performed a comprehensive survey of 17,319 clinical NSCLC samples (14,170 adenocarcinomas and 3149 NSCLC not otherwise specified (NOS)) and identified 5 cases of FGFR3-TACC3 containing the intact kinase domain of FGFR3 and the coiled-coil domain of TACC3 emerging after treatment with EGFR TKIs, including one previously reported index case. Of the 4 novel cases of FGFR3-TACC3, one emerged after erlotinib, one after afatinib, one after osimertinib, and one after ASP8273. These 5 cases of FGFR3-TACC3 fusions acquired post-EGFR TKI, while rare, indicate that FGFR3-TACC3 is a recurrent resistance mechanism, which can bypass EGFR blockade by all generations of EGFR TKIs in NSCLC. Routine re-biopsy and genomic profiling using platforms capable of detecting kinase fusions has the potential to inform new therapeutic strategies for patients with EGFR-mutant NSCLC progressing on TKIs.
Simon VB,Fong A,Nageotte MP
Supplemental Oxygen Study: A Randomized Controlled Study on the Effect of Maternal Oxygen Supplementation during Planned Cesarean Delivery on Umbilical Cord Gases.
Am J Perinatol. 2017 Aug 24;
Hasan R,Srinivasan R,Grossman ED
Feature-based attentional tuning during biological motion detection measured with SSVEP.
J Vis. 2017 Aug 01;17(9):22
Performance in detection tasks can be improved by directing attention to task-relevant features. In this study, we evaluate the direction tuning of selective attention to motion features when observers detect point-light biological motion in noise. Feature-based attention strategy is assessed by capitalizing on the sensitivity of unattended steady-state visual-evoked potential (SSVEP) to the spreading of feature-based attention to unattended regions of space. Participants monitored for the presence of a point-light walker embedded in uniform dynamic noise in the center of the screen. We analyzed the phase-locked electroencephalogram response to a flickering random-dot kinematogram (RDK) in an unattended peripheral annulus for the 1 s prior to the onset of the target. We found the highest SSVEP power to originate from electrodes over posterior parietal cortex (PPC), with power modulated by the direction of motion in the unattended annulus. The SSVEP was strongest on trials in which the unattended motion was opposite the facing direction of the walker, consistent with the backstroke of the feet and with the global direction of perceived background motion from a translating walker. Coherence between electrodes over PPC and other brain regions successfully predicted individual participant's d-prime, with the highest regression coefficients at electrodes over ventrolateral prefrontal cortex (VLPFC). The findings are evidence that functional connectivity between frontal and parietal cortex promote perceptual feature-based attention, and subsequent perceptual sensitivity, when segregating point-light figures from masking surround.
Potkin SG,Loze JY,Forray C,Baker RA,Sapin C,Peters-Strickland T,Beillat M,Nylander AG,Hertel P,Nitschky Schmidt S,Ettrup A,Eramo A,Hansen K,Naber D
Relationship between response to aripiprazole once-monthly and paliperidone palmitate on work readiness and functioning in schizophrenia: A post-hoc analysis of the QUALIFY study.
PLoS One. 2017;12(8):e0183475
Schizophrenia is a chronic disease with negative impact on patients' employment status and quality of life. This post-hoc analysis uses data from the QUALIFY study to elucidate the relationship between work readiness and health-related quality of life and functioning. QUALIFY was a 28-week, randomized study (NCT01795547) comparing the treatment effectiveness of aripiprazole once-monthly 400 mg and paliperidone palmitate once-monthly using the Heinrichs-Carpenter Quality-of-Life Scale as the primary endpoint. Also, patients' capacity to work and work readiness (Yes/No) was assessed with the Work Readiness Questionnaire. We categorized patients, irrespective of treatment, by work readiness at baseline and week 28: No to Yes (n = 41), Yes to Yes (n = 49), or No at week 28 (n = 118). Quality-of-Life Scale total, domains, and item scores were assessed with a mixed model of repeated measures. Patients who shifted from No to Yes in work readiness showed robust improvements on Quality-of-Life Scale total scores, significantly greater than patients not ready to work at week 28 (least squares mean difference: 11.6±2.6, p
Lu Y,Zamora-Ros R,Chan S,Cross AJ,Ward H,Jakszyn P,Luben R,Opstelten JL,Oldenburg B,Hallmans G,Karling P,Grip O,Key T,Bergmann MM,Boeing H,Overvad K,Palli D,Masala G,Khaw KT,Racine A,Carbonnel F,Boutron-Ruault MC,Andersen V,Olsen A,Tjonneland A,Kaaks R,Tumino R,Trichopoulou A,Scalbert A,Riboli E,Hart AR
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC).
Inflamm Bowel Dis. 2017 Aug 22;
Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.