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O'Brien SM
Highlights From the XVII International Workshop on Chronic Lymphocytic Leukemia: Commentary.
Clin Adv Hematol Oncol. 2017 Jul;15 Suppl 6(7):13-15
PMID: 28837123

Malacrida L,Jameson DM,Gratton E
A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes.
Sci Rep. 2017 Aug 23;7(1):9215
Mammalian cell membranes have different phospholipid composition and cholesterol content, displaying a profile of fluidity that depends on their intracellular location. Among the dyes used in membrane studies, LAURDAN has the advantage to be sensitive to the lipid composition as well as to membrane fluidity. The LAURDAN spectrum is sensitive to the lipid composition and dipolar relaxation arising from water penetration, but disentangling lipid composition from membrane fluidity can be obtained if time resolved spectra could be measured at each cell location. Here we describe a method in which spectral and lifetime information obtained in different measurements at the same plane in a cell are used in the phasor plot providing a solution to analyze multiple lifetime or spectral data through a common visualization approach. We exploit a property of phasor plots based on the reciprocal role of the phasor plot and the image. In the phasor analysis each pixel of the image is associated with a phasor and each phasor maps to pixels and features in the image. In this paper the lifetime and spectral fluorescence data are used simultaneously to determine the contribution of polarity and dipolar relaxations of LAURDAN in each pixel of an image.
PMID: 28835608

Boudová S,Walldorf JA,Bailey JA,Divala T,Mungwira R,Mawindo P,Pablo J,Jasinskas A,Nakajima R,Ouattara A,Adams M,Felgner PL,Plowe CV,Travassos MA,Laufer MK
Mother-newborn pairs in Malawi have similar antibody repertoire to diverse malaria antigens.
Clin Vaccine Immunol. 2017 Aug 23;
Maternal antibodies may play a role in protecting newborns against malaria disease. Plasmodium falciparum parasite surface antigens are diverse and protection from infection requires allele-specific immunity. Although malaria-specific antibodies have been shown to cross the placenta, the extent to which antibodies that respond to the full repertoire of diverse antigens are transferred from the mother to the infant has not been explored. Understanding the breadth of maternal antibody responses and to what extent these antibodies are transferred to the child can inform vaccine design and evaluation.
PMID: 28835359

Sahyouni R,Haidar YM,Moshtaghi O,Wang BY,Djalilian HR,Middlebrooks JC,Lin HW
Selective Stimulation of Facial Muscles Following Chronic Intraneural Electrode Array Implantation and Facial Nerve Injury in the Feline Model.
Otol Neurotol. 2017 Aug 22;
Our group has previously shown that activation of specific facial nerve (FN) fiber populations and selective activation of facial musculature can be achieved through acute intraneural multichannel microelectrode array (MEA) implantation in the feline model.
PMID: 28834941

Baena-Díaz F,Fornoni J,Sosenski P,Weller SG,Domínguez CA
Pollen and stigma size changes during the transition from tristyly to distyly in Oxalis alpina (Oxalidaceae).
Plant Biol (Stuttg). 2017 Aug 23;
(1)Pollen and stigma size have the potential of influencing male fitness of hermaphroditic plants, particularly in species presenting floral polymorphisms characterized by marked differences in these traits among floral morphs. In this study, we take advantage of the evolutionary transition from tristyly to distyly experienced by Oxalis alpina (Oxalidaceae) and examined whether modifications in the ancillary traits (pollen and stigma size) respond to allometric changes in other floral traits. Also, we tested if these modifications are in accordance with what would be expected under the hypothesis that novel competitive scenarios (as in distylous derived reproductive system) exerts morph- and whorl-specific selective pressures to match the available stigmas. (2) We measure pollen- and stigma size in five populations of O. alpina representing the tristyly-distyly transition. (3) A general reduction in pollen and stigma size occurred along the tristyly-distyly transition and pollen size from the two anther levels within each morph converged to a similar size that was characterized by whorl specific changes (increases or decreases) in pollen size of different anthers in each floral type. (4) Overall, results from this study show that the evolution of distyly in this species is characterized not only by changes in sexual organ position and flower size, but also by morph-specific changes in pollen and stigma size. This evidence supports the importance of selection on pollen and stigma size that increase fitness of remaining morphs following the evolution of distyly, and raises questions to explore the functional value of pollen size in heterostylous systems under pollen competition. This article is protected by copyright. All rights reserved.
PMID: 28834046

Dobson M,Choi B,Schnall PL
Work organization, health, and obesity in urban transit operators: A qualitative study.
Am J Ind Med. 2017 Aug 18;
Urban transit operators have high rates of obesity, hypertension, and other cardiovascular risk-factors compared to other occupations. There have been few qualitative studies exploring the interrelationships between the organization of transit work, stress, and health including obesity, from the perspective of operators.
PMID: 28833399

Merna C,Kita A,Wester J,Diaz-Aguilar D,Goldstein JD,Palma Diaz F,Blackwell K,St John MA
Intraosseous mucoepidermoid carcinoma: Outcome review.
Laryngoscope. 2017 Aug 22;
Identify the effect of patient characteristics, disease traits, and treatment modality on patient outcomes in the rare disease process of intraosseous mucoepidermoid carcinoma.
PMID: 28833169

Chalkia D,Singh LN,Leipzig J,Lvova M,Derbeneva O,Lakatos A,Hadley D,Hakonarson H,Wallace DC
Association Between Mitochondrial DNA Haplogroup Variation and Autism Spectrum Disorders.
JAMA Psychiatry. 2017 Aug 23;
Autism spectrum disorders (ASD) are characterized by impairments in social interaction, communication, and repetitive or restrictive behavior. Although multiple physiologic and biochemical studies have reported defects in mitochondrial oxidative phosphorylation in patients with ASD, the role of mitochondrial DNA (mtDNA) variation has remained relatively unexplored.
PMID: 28832883

Hasan A,Chung PC,Hayes W
Graphettes: Constant-time determination of graphlet and orbit identity including (possibly disconnected) graphlets up to size 8.
PLoS One. 2017;12(8):e0181570
Graphlets are small connected induced subgraphs of a larger graph G. Graphlets are now commonly used to quantify local and global topology of networks in the field. Methods exist to exhaustively enumerate all graphlets (and their orbits) in large networks as efficiently as possible using orbit counting equations. However, the number of graphlets in G is exponential in both the number of nodes and edges in G. Enumerating them all is already unacceptably expensive on existing large networks, and the problem will only get worse as networks continue to grow in size and density. Here we introduce an efficient method designed to aid statistical sampling of graphlets up to size k = 8 from a large network. We define graphettes as the generalization of graphlets allowing for disconnected graphlets. Given a particular (undirected) graphette g, we introduce the idea of the canonical graphette [Formula: see text] as a representative member of the isomorphism group Iso(g) of g. We compute the mapping [Formula: see text], in the form of a lookup table, from all 2k(k - 1)/2 undirected graphettes g of size k ≤ 8 to their canonical representatives [Formula: see text], as well as the permutation that transforms g to [Formula: see text]. We also compute all automorphism orbits for each canonical graphette. Thus, given any k ≤ 8 nodes in a graph G, we can in constant time infer which graphette it is, as well as which orbit each of the k nodes belongs to. Sampling a large number N of such k-sets of nodes provides an approximation of both the distribution of graphlets and orbits across G, and the orbit degree vector at each node.
PMID: 28832661

Okhunov Z,Farhan B,Ahmed A,Pulford C,Ghoniem G
Surgical technique for removal of tined lead for InterStim.
Can J Urol. 2017 Aug;24(4):8918-8920
We aimed to introduce our technique describing the removal of a chronic implanted tined-lead in patients with a sacral neuromodulator implant.
PMID: 28832311

Fujisawa M,Sakata-Yanagimoto M,Nishizawa S,Komori D,Gershon P,Kiryu M,Tanzima S,Fukumoto K,Enami T,Muratani M,Yoshida K,Ogawa S,Matsue K,Nakamura N,Takeuchi K,Izutsu K,Fujimoto K,Teshima T,Miyoshi H,Gaulard P,Ohshima K,Chiba S
Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma.
Leukemia. 2017 Aug 23;
Somatic G17V RHOA mutations were found in 50-70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling. Here, we discovered the novel function of the G17V RHOA: VAV1 was identified as a G17V RHOA-specific binding partner via high throughput screening. We found that binding of G17V RHOA to VAV1 augmented its adaptor function through phosphorylation of 174Tyr, resulting in acceleration of T-cell receptor (TCR) signaling. Enrichment of cytokine and chemokine-related pathways was also evident by the expression of G17V RHOA. We further identified VAV1 mutations and a new translocation, VAV1-STAP2, in seven of the 85 RHOA mutation-negative samples (8.2%), while none of the 41 RHOA mutation-positive samples exhibited VAV1 mutations. Augmentation of 174Tyr phosphorylation was demonstrated also in VAV1-STAP2. Dasatinib, a multi-kinase inhibitor, efficiently blocked the accelerated VAV1 phosphorylation and the associating TCR signaling by both G17V RHOA and VAV1-STAP2 expression. Phsopho-VAV1 staining was demonstrated in the clinical specimens harboring G17V RHOA and VAV1 mutations at a higher frequency than those without. Our findings indicate that the G17V RHOA-VAV1 axis may provide a new therapeutic target in AITL.Leukemia accepted article preview online, 23 August 2017. doi:10.1038/leu.2017.273.
PMID: 28832024

Mahboubi H,Haidar YM,Kiumehr S,Ziai K,Djalilian HR
Customized Versus Noncustomized Sound Therapy for Treatment of Tinnitus: A Randomized Crossover Clinical Trial.
Ann Otol Rhinol Laryngol. 2017 Aug 01;:3489417725093
To determine the effectiveness of a customized sound therapy and compare its effectiveness to that of masking with broadband noise.
PMID: 28831839

Clair K,Wolford J,Veran-Taguibao S,Kim G,Eskander RN
Primary low-grade endometrial stromal sarcoma of the omentum.
Gynecol Oncol Rep. 2017 Aug;21:119-121
?Extra-uterine endometrial stromal sarcoma may arise in endometriosis.?Abdominal exploration for extra pelvic endometriosis is warranted.?Representative endometriotic implants should be resected and/or biopsied if clinically suspicious.
PMID: 28831418

Ray JV,Frick PJ,Thornton LC,Wall Myers TD,Steinberg L,Cauffman E
Callous-unemotional traits predict self-reported offending in adolescent boys: The mediating role of delinquent peers and the moderating role of parenting practices.
Dev Psychol. 2017 Feb;53(2):319-328
Research has only recently begun to examine how callous-unemotional (CU) traits interact with contextual factors to predict delinquent behavior. The current study attempts to explain the well-established link between CU traits and offending by testing the potential mediating and moderating roles of 2 critical contextual factors: peer delinquency and the quality of the parent-adolescent relationship among a sample of 1,216 male juvenile offenders. Youth in the study were interviewed once every 6 months and in the current analyses, CU traits measured at baseline, parenting and delinquent peer association measured during the 6-month interview, and offending measured at the 1-year interview were utilized in path analysis. The findings suggested that the effect of CU traits was partially mediated by delinquent peer association. Additionally, it was found that when both parental warmth and supervision were high, this indirect effect through delinquent peer association was no longer significant. The findings highlight the importance of specific aspects of parenting in reducing delinquent peer influence, particularly among youth with high levels of CU traits. (PsycINFO Database Record
PMID: 27748621

Emerson JJ
Evolution: A Paradigm Shift in Snake Sex Chromosome Genetics.
Curr Biol. 2017 Aug 21;27(16):R800-R803
The belief that all snakes possess ZW sex chromosomes has prevailed for decades, despite no evidence of this in boas, pythons, and their relatives. A recent discovery of male-specific genetic markers reveals that these snakes instead possess XY sex chromosomes.
PMID: 28829965

Chang AL,Yu HJ,von Borstel D,Nozaki T,Horiuchi S,Terada Y,Yoshioka H
Advanced Imaging Techniques of the Wrist.
AJR Am J Roentgenol. 2017 Sep;209(3):497-510
This article covers the technical aspects and clinical applications of recent advancements in wrist MRI techniques, including T2 and T1rho mapping, compressed sensing, and isotropic 3D imaging using driven equilibrium sequences, variable-flip-angle refocusing pulse sequences, and parallel imaging. The clinical applications of these techniques include the quantitative analysis of cartilage and triangular fibrocartilaginous complex (TFCC) degeneration, faster scanning times, and improved resolution of complex wrist anatomy, allowing differentiation of degenerative from traumatic TFCC tears and improved morphologic evaluation of chondromalacia.
PMID: 28829171

Samy RA,George D,Sen AK
Bio-inspired liquid transport via elastocapillary interaction of a thin membrane with a liquid meniscus.
Soft Matter. 2017 Aug 22;
We report bio-inspired (from a hummingbird's tongue) liquid transport via elastocapillary interaction of a thin membrane with a liquid meniscus. A soft wedge-thin rectangular membrane forming a wedge with a rigid substrate and a flat thin rectangular membrane undergo large deformation while interacting with liquid menisci. The membrane deformation leads to the formation of confinement which in turn results in elastocapillary flow along the membrane length. A simple theoretical model based on the Euler Bernoulli law is used to predict the membrane deformation profiles, which compare well with that obtained from experiments. In the wedge case, the membrane surface and liquid are selected such that the Concus-Finn criterion is not satisfied to contrast the present case of elastocapillary flow from the typical corner flow reported in the literature. The meniscus location versus time studies indicated that the flow exhibits the typical Washburn regime with , except for a sudden increase in velocity at the end of the membrane length. The effects of membrane thickness and width, liquids and substrates were studied to determine the expression for the modified Washburn constant Wm in both the wedge and flat membranes. It was found that gravity plays a role for Bo > 0.94 and for Bo = 1.9, the effect of inclination angle on the flow was studied. The elastocapillary flow with thin membranes could open up an opportunity for a new area, namely "membrane microfluidics" or "lab on a membrane", for diagnostics and other applications.
PMID: 28828452

Kothari MM,Nguyen DL,Parekh NK
Strategies for overcoming anti-tumor necrosis factor drug antibodies in inflammatory bowel disease: Case series and review of literature.
World J Gastrointest Pharmacol Ther. 2017 Aug 06;8(3):155-161
Anti-tumor necrosis factor (TNF) biologics are currently amongst the most widely used and efficacious therapies for inflammatory bowel disease (IBD). The development of therapeutic drug monitoring for infliximab and adalimumab has allowed for measurement of drug levels and antidrug antibodies. This information can allow for manipulation of drug therapy and prediction of response. It has been shown that therapeutic anti-TNF drug levels are associated with maintenance of remission, and development of antidrug antibodies is predictive of loss of response. Studies suggest that a low level of drug antibodies, however, can at times be overcome by dose escalation of anti-TNF therapy or addition of an immunomodulator. We describe a retrospective case series of twelve IBD patients treated at the University of California-Irvine, who were on infliximab or adalimumab therapy and were found to have detectable but low-level antidrug antibodies. These patients underwent dose escalation of the drug or addition of an immunomodulator, with subsequent follow-up drug levels obtained. Eight of the twelve patients (75%) demonstrated resolution of antidrug antibodies, and were noted to have improvement in disease activity. Though data regarding overcoming low-level anti-TNF drug antibodies remains somewhat limited, cases described in the literature as well as our own experience suggest that this may be a viable strategy for preserving the use of an anti-TNF drug. Low-level anti-TNF drug antibodies may be overcome by dose escalation and/or addition of an immunomodulator, and can allow for clinical improvement in disease status. Therapeutic drug monitoring is an important tool to guide this strategy.
PMID: 28828193

Hermosilla J,Fernandez P,Ferreira L,Maltes M
[Hydroureteronephrosis secondary to abdominal wall hematoma].
Medicina (B Aires). 2017;77(4):330
PMID: 28825579

Schenke K,Nguyen T,Watts TW,Sarama JH,Clements DH
Differential effects of the classroom on African American and non-African American's mathematics achievement.
J Educ Psychol. 2017 Aug;109(6):794-811
We examined whether African American students differentially responded to dimensions of the observed classroom-learning environment compared with non-African American students. Further, we examined whether these dimensions of the classroom mediated treatment effects of a preschool mathematics intervention targeted at students from low-income families. Three observed dimensions of the classroom (teacher expectations and developmental appropriateness; teacher confidence and enthusiasm; and support for mathematical discourse) were evaluated in a sample of 1,238 preschool students in 101 classrooms. Using multigroup multilevel mediation where African American students were compared to non-African American students, we found that teachers in the intervention condition had higher ratings on the observed dimensions of the classroom compared with teachers in the control condition. Further, ratings on teacher expectations and developmental appropriateness had larger associations with the achievement of African American students than for non-African Americans. Findings suggest that students within the same classroom may react differently to that learning environment and that classroom learning environments could be structured in ways that are beneficial for students who need the most support.
PMID: 28824200

Saad A,Binder PS,Gatinel D
Evaluation of the percentage tissue altered as a risk factor for developing post-laser in situ keratomileusis ectasia.
J Cataract Refract Surg. 2017 Jul;43(7):946-951
To assess the currently recommended percentage tissue altered (PTA) metric for its ability to screen for ectasia after laser in situ keratomileusis (LASIK).
PMID: 28823442

Quesnel KJ,Ajami NK,Wyss N
Accelerating the Integration of Distributed Water Solutions: A Conceptual Financing Model from the Electricity Sector.
Environ Manage. 2017 Aug 19;
Modern challenges require new approaches to urban water management. One solution in the portfolio of potential strategies is the integration of distributed water infrastructure, practices, and technologies into existing systems. However, many practical barriers have prevented the widespread adoption of these systems in the US. The objective of this paper is to address these challenges by developing a conceptual model encompassing regulatory, financial, and governance components that can be used to incorporate new distributed water solutions into our current network. To construct the model, case studies of successfully implemented distributed electricity systems, specifically energy efficiency and renewable energy technologies, were examined to determine how these solutions have become prominent in recent years and what lessons can be applied to the water sector in a similar pursuit. The proposed model includes four action-oriented elements: catalyzing change, establishing funding sources, using resource pathways, and creating innovative governance structures. As illustrated in the model, the water sector should use suite of coordinated policies to promote change, engage end users through fiscal incentives, and encourage research, development and dissemination of new technologies over time.
PMID: 28823071

Bailey DH,Nguyen T,Jenkins JM,Domina T,Clements DH,Sarama JS
Fadeout in an early mathematics intervention: Constraining content or preexisting differences?
Dev Psychol. 2016 Sep;52(9):1457-69
A robust finding across research on early childhood educational interventions is that the treatment effect diminishes over time, with children not receiving the intervention eventually catching up to children who did. One popular explanation for fadeout of early mathematics interventions is that elementary school teachers may not teach the kind of advanced content that children are prepared for after receiving the intervention, so lower-achieving children in the control groups of early mathematics interventions catch up to the higher-achieving children in the treatment groups. An alternative explanation is that persistent individual differences in children's long-term mathematical development result more from relatively stable preexisting differences in their skills and environments than from the direct effects of previous knowledge on later knowledge. We tested these 2 hypotheses using data from an effective preschool mathematics intervention previously known to show a diminishing treatment effect over time. We compared the intervention group to a matched subset of the control group with a similar mean and variance of scores at the end of treatment. We then tested the relative contributions of factors that similarly constrain learning in children from treatment and control groups with the same level of posttreatment achievement and preexisting differences between these 2 groups to the fadeout of the treatment effect over time. We found approximately 72% of the fadeout effect to be attributable to preexisting differences between children in treatment and control groups with the same level of achievement at posttest. These differences were fully statistically attenuated by children's prior academic achievement. (PsycINFO Database Record
PMID: 27505700

Mangale V,Marro BS,Plaisted WC,Walsh CM,Lane TE
Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus.
Virology. 2017 Aug 16;511:49-55
The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed.
PMID: 28822268

Wang X,Chemmama IE,Yu C,Huszagh A,Xu Y,Viner R,Block SA,Cimermancic P,Rychnovsky SD,Ye Y,Sali A,Huang L
The Proteasome-Interacting Ecm29 Protein Disassembles the 26S Proteasome in Response to Oxidative Stress.
J Biol Chem. 2017 Aug 15;
Oxidative stress has been implicated in multiple human neurological and other disorders. Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged proteins. To understand stress-associated human pathologies, it is important to uncover the molecular events underlying the regulation of proteasomes upon oxidative stress. To this end, we investigated H2O2 stress-induced molecular changes of the human 26S proteasome and determined that stress-induced 26S proteasome disassembly is conserved from yeast to human. Moreover, we developed and employed a new proteomic approach, XAP (in vivo crosslinking (x)-assisted affinity purification) coupled with stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative MS, to capture and quantify several weakly bound proteasome-interacting proteins (PIPs) and examine their roles in stress-mediated proteasomal remodeling. Our results indicated that the adapter protein Ecm29 is the main PIP responsible for the stress-triggered remodeling of the 26S proteasome in human cells. Importantly, using a newly developed disuccinimidyl sulfoxide (DSSO)-based crosslinking MS platform, we mapped the interactions of Ecm29 within itself and with proteasome subunits and thereby determined the architecture of the Ecm29-proteasome complex with integrative structure modeling. These results enabled us to propose a structural model in which Ecm29 intrudes on the interaction between the 20S core particle and the 19S regulatory particle in the 26S proteasome, thereby disrupting the proteasome structure in response to oxidative stress.
PMID: 28821611

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