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Kelly PT,Cotman CW
University of California, Department of Psychobiology, Irvine, CA 92717, USA.
Intermolecular disulfide bonds at central nervous system synaptic junctions.
Biochem Biophys Res Commun. 1976 Dec 20;73(4):858-64
Most proteins in isolated synaptic junctions and nearly all those in postsynaptic densities (the fibrous protein matrix underlying the postsynaptic membrane at the synapse) are extensively cross-linked by disulfide bonds into polymers with a molecular weight of 350,000 or greater. Since the postsynaptic density appears to consist primarily of a matrix of cytoplasmic proteins, such as tubulin and neurofilament protein, our results indicate that at the membrane such proteins may use disulfide bonds to differentiate into the postsynaptic density and tie into the postsynaptic membrane.
PMID: 15625853

Kelly PT,Luttges MW
Department of Psychobiology, University of California, Irvine, Irvine, CA 92717, USA.
Mouse brain protein composition during postnatal development: an electrophoretic analysis.
J Neurochem. 1976 Nov;27(5):1163-72
Changes in the concentrations of mouse brain proteins during postnatal maturation were characterized by a combination of subcellular fractionation and electrophoresis. Sodium dodecyl sulfate gel electrophoresis revealed changing protein concentrations in fractions enriched in nuclei, mitochondria plus synaptic endings, microsomes and cytosol. Postnatal maturational changes in protein concentrations were most pronounced in fractions of purified myelin membranes. The use of exponential gradient gels resulted in increased resolution of low molecular weight myelin proteins. Nuclei treated with Triton X-100 exhibited no change in relative histone concentrations during brain maturation. Nonnuclear contamination of untreated nuclear fractions was shown to be a potential source of erroneous interpretations. These findings are discussed in terms of genetic products and sodium dodecyl sulfate polyacrylamide gel electrophoresis resolution.
PMID: 12170603

Hartle JT
University of California, 92664, Irvine, California.
Facilitation of recall with intralist cues: Time-dependent characteristics of cued recall.
Mem Cognit. 1976 Sep;4(5):471-5
List items were given as retrieval cues in a free-recall experiment which factorially combined the presence or absence of cues with the amount of time allowed for use of each cue (10 sec or 30 sec). A categorizable list of 75 randomly presented words was learned, and 48 h later a free-recall test trial was given, followed by a final memory search task. During the final task, cued subjects received words from categories that had not been recalled during the free-recall test. With both time intervals, cued subjects recalled more words than noncued subjects, indicating that random presentation of categorized words does not necessarily preclude the observation of a cueing effect with list items, as has been reported previously. The composition of recall, whether from previously recalled or nonrecalled categories, varied as a function of time for both groups. The results were interpreteod in terms of retrieval strategies employed by cued and noncued subjects and the effect of time on these strategies.
PMID: 21286969

Meeker RR,Thomas JR,Tewari KK
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92664.
In vitro iodination of plant ribonucleic acids.
Plant Physiol. 1976 Jul;58(1):71-6
The optimum conditions for in vitro iodination of RNAs have been established which yield specific radioactivities ranging from 10 x 10(4) to 10 x 10(6) cpm/mug. A nomogram has been constructed by correlating specific radioactivities of RNA with concentration of KI, RNA, and (125)I. This nomogram can be used to determine the conditions for the desired specific radioactivities for any unknown RNA. The in vitro iodinated RNA has been compared with in vivo labeled RNA for hybridization characteristics. Competition hybridization between (125)I-labeled chloroplast-rRNA and unlabeled pea (Pisum sativum) chloroplast-rRNA was identical to that found using [(32)P]chloroplast-rRNA. Thermal stability of DNA-(125)I-rRNA hybrids was similar to the thermal stability of DNA-[(32)P]rRNA hybrids. The iodinated RNA was not found to have undergone any changes in its hydrogen-bonding properties.
PMID: 16659624

Gottschalk LA
Department of Psychiatry and Human Behavior, California College of Medicine, University of California at Irvine, Irvine, California.
Children's speech as a source of data toward the measurement of psychological states.
J Youth Adolesc. 1976 Mar;5(1):11-36
A measurement of psychological states, based on the objective content analysis of small samples of speech, has undergone thorough reliability and constructvalidation studies for individuals in the age range 17-70. The present report is a first step in the extension of this method to children ages 6-16. It has involved a descriptive analysis of the frequency of use of various verbal content categories of 109 schoolchildren, roughly stratified for grade. Percentile scores have been obtained for such content analysis scales as anxiety, hostility outward, hostility inward, ambivalent hostility, social alienation-personal disorganization, cognitive impairment, human relations, hope, and achievement strivings. Comparisons are made between these children's scores on such measures and similar scores obtained from adults. Sex differences and developmental trends are examined.
PMID: 24407969

Pattison EM
University of California at Irvine, Irvine, USA.
Notes on the current quest for gender identity.
J Relig Health. 1975 Apr;14(2):82-95
PMID: 24408792

Pick JB
Department of Population and Environmental Biology, University of California, 92664, Irvine, California.
Computer display of population age structure.
Demography. 1974 Nov;11(4):673-82
The standard human population pyramid contains only current information; it is often inadequate when making comparisons of different countries or years. A graphic computer program superimposes current population, life table survivor ships, stable population, and past population projected up to the present. Fertility, health conditions, migration, and demographic transition stage are better revealed by this expanded graph form. A time series of the modified pyramids reveals detailed age-specific trends for a country or region. With 'minor modifications the computer program is applicable to all machines with a Fortran IV compiler.
PMID: 21279752

Herr HW,Silber I,Martin DC
Department of Surgery (Urology), University of California, Irvine, California, USA.
Bedside sphincterometry.
Urology. 1974 Jul;4(1):57-9
We describe the use of a simple bedside sphinctermometer which has proved valuable and reliable in the practical evaluation and management of those patients with neurogenic bladder dysfunction.
PMID: 21322984

Basu PS,Tuli V
College of Medicine, University of California, Irvine, California 92664.
The Binding of Indole-3-acetic Acid and 3-Methyleneoxindole to Plant Macromolecules.
Plant Physiol. 1972 Oct;50(4):507-9
Homogenates of pea (Pisum sativum L., var. Alaska) seedlings exposed to (14)C-indole-3-acetic acid or (14)C-3-methyleneoxindole, an oxidation product of indole-3-acetic acid, were extracted with phenol. In both cases 90% of the bound radioactivity was found associated with the protein fraction and 10% with the water-soluble, ethanol-insoluble fraction. The binding of radioactivity from (14)C-indole-3-acetic acid is greatly reduced by the addition of unlabeled 3-methyleneoxindole as well as by chlorogenic acid, an inhibitor of the oxidation of indole-3-acetic acid to 3-methyleneoxindole. Chlorogenic acid does not inhibit the binding of (14)C-3-methyleneoxindole. The labeled protein and water-soluble, ethanol-insoluble fractions of the phenol extract were treated with an excess of 2-mercaptoethanol. Independently of whether the seedlings had been exposed to (14)C-indole-3-acetic acid or (14)C-3-methyleneoxindole, the radioactivity was recovered from both fractions in the form of a 2-mercaptoethanol-3-methyleneoxindole adduct. These findings indicate that 3-methyleneoxindole is an intermediate in the binding of indole-3-acetic acid to macromolecules.
PMID: 16658206

Basu PS,Tuli V
College of Medicine, University of California, Irvine, California 92664.
Enzymatic dehydration of 3-hydroxymethyloxindole.
Plant Physiol. 1972 Oct;50(4):503-6
Crude and partially purified extracts of wheat (Triticum vulgare, red variety) germ catalyze the dehydration of 3-hydroxymethyloxindole to 3-methyleneoxindole. Examination of the ultraviolet absorption spectrum of a reaction mixture consisting of either the extract or partially purified enzyme and 3-hydroxymethyloxindole, shows that this oxindole has undergone complete dehydration to 3-methyleneoxindole. TPNH-linked 3-methyleneoxindole reductase, also a constituent of the wheat germ extract, can be separated from the dehydrase by passage through an Agarose 15 column. Utilizing these partially purified enzymes, it can be demonstrated that the dehydrase activity found in wheat germ is a discrete enzymatic function.
PMID: 16658205

Basu PS,Tuli V
College of Medicine, University of California, Irvine, California 92664.
Auxin activity of 3-methyleneoxindole in wheat.
Plant Physiol. 1972 Oct;50(4):499-502
A product of the enzymatic oxidation of indole-3-acetic acid, 3-methyleneoxindole, is at least 50-fold more effective than indole-3-acetic acid in stimulating the growth of wheat (Triticum vulgare, red variety) coleoptiles. Ethylenediaminetetra-acetic acid can antagonize the growth-stimulating properties of the parent compound, indole-3-acetic acid, presumably by chelating Mn(2+), which is required for the enzymatic oxidation of indole-3-acetic acid. The growth stimulating effect of 3-methyleneoxindole, a product of the blocked reaction, on the other hand, is still evident in the presence of ethylenedia-minetetraacetic acid. In the presence of 2-mercaptoethanol, indole-3-acetic acid fails to stimulate the elongation of wheat coleoptiles. The property of binding to sulfhydryl compounds including 2-mercaptoethanol is unique to 3-methyleneoxindole among indole-3-acetic acid and its oxidation products. These findings suggest that 3-methyleneoxindole is an obligatory intermediate in indole-3-acetic acid induced elongation of wheat coleoptiles.
PMID: 16658204

Campbell RD
Department of Developmental and Cell Biology, University of California, Irvine, California 92664, USA.
Statocyst lacking cilia in the coelenterate Corymorpha palma.
Nature. 1972 Jul 7;238(5358):49-50
PMID: 12635277

Carrier JM
School of Social Sciences, University of California, Irvine, California, USA.
Participants in urban Mexican male homosexual encounters.
Arch Sex Behav. 1971 Dec;1(4):279-91
Preliminary data are presented on 53 urban Mexican males interviewed during 1970-1971 in a study of homosexual encounters in a large Mexican city. These data are compared with data from recent studies in the United States and England of male homosexual behavior. Although preliminary and limited, the Mexican data indicate that cultural factors are important determinants of life styles and sex practices of homosexual males. Forty-eight of the 53 (90%) preferred and usually practiced anal intercourse, four preferred oral contacts, and one preferred mutual masturbation. Interviewees were also grouped according to major type of sex activity during the first sustained year of homosexual activity after puberty. One intragroup comparison indicates significant differences between anal active and anal passive interviewees. For example, as children anal passive subjects had significantly more homosexual contacts with adults; they also considered themselves more effeminate and as children were more involved with female sex-typed activities. Comparison of data from the English and United States studies with the present data suggests that preference for a particular sexual technique is not as developed in the former two countries; when there is a preference, it is not usually for anal intercourse.
PMID: 24179076

Atsatt PR
Department of Population and Environmental Biology, University of California, Irvine 92664, USA.
Hemiparasitic flowering plants: phenotypic canalization by hosts.
Nature. 1970 Mar 21;225(5238):1161-3
PMID: 16056963

Gerard RW
Computer-assisted learning: introduction and general considerations.
Proc Natl Acad Sci U S A. 1969 Jul;63(3):573-9
PMID: 16591765

Kurnick NB,Nokay N
Department of Medicine, University of California at Irvine, Long Beach Veterans Administration Hospital, Long Beach, California, USA.
Hematological response to isologous and homologous bone marrow transplantation: mechanism of homologous failure.
Radiat Res. 1968 Oct;36(1):31-44
C3H mice (H-2 locus = k, hemoglobin D) received marrow cells intravenously following supralethal total-body x-irradiation. Donors were C3H, AKR (k, hemoglobin D), C57BR (k, hemoglobin S), A (a, hemoglobin D), and C57BL (b, hemoglobin S). Compatible marrow recipients suffered 20 % mortality. Incompatible H-2 and hemoglobin donation resulted in 97 % (mortality by the twenty-fifth day. H-2-compatible, hemoglobin-incompatible recipients suffered 67 % mortality by the fortieth day and then no further mortality. The H-2-incompatible, hemoglobin-compatible donation resulted in 36 % mortality by the fortieth day and showed continued mortality thereafter. Peripheral blood hematocrit and granulocyte counts and bone marrow cellularity and DNase activity revealed no significant differences, demonstrating successful grafts in all groups. However, the recovery of peripheral blood lymphocytes was inversely related to the mortality. Lymphopoiesis is apparently inhibited when the transplanted lymphocytes encounter overwhelming concentration of foreign antigens in the host. The H-2-compatible, hemoglobin-incompatible graft replaces the host's erythrocytes, thereby eliminating the inhibition of the graft's lymphocytic proliferation by that host antigen. During the first 40 days, homologous deaths result primarily from the effects of lymphopenia; thereafter, with recovery of lymphopoiesis, deaths are probably due to graft versus host reaction.
PMID: 17387924

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